{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T14:22:18Z","timestamp":1791469338784,"version":"4.3.4"},"reference-count":62,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T00:00:00Z","timestamp":1579564800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We studied neurodevelopmental and behavioral\/emotional symptoms in patients with Duchenne muscular dystrophy (DMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Retrospective case series of neurodevelopmental and behavioral\/emotional symptoms obtained through review of systems of 700 DMD patients in relation to dystrophin gene mutations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common symptoms encountered were emotional\/behavioral dysregulation (38.7%), inattention\/hyperactive features (31.4%), obsessive and compulsive features (25.0%), and language\/speech delays (24.4%). Most patients (72.7%) had at least one symptom. Patients with mutations near the 3\u2032 end of the dystrophin gene were at higher risk for developing inattention\/hyperactive features, language\/speech delays, and global intellectual delays. Those with mutations between exon 31 and 79 had higher risk of clustering of symptoms when compared with those upstream of exon 30.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Neurodevelopmental, emotional, and behavioral symptoms are common comorbidities in DMD. There is higher prevalence of inattention\/hyperactive features, language\/speech delays, and global intellectual delays in genotypes affecting the 3\u2032 end of the dystrophin gene.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26803","type":"journal-article","created":{"date-parts":[[2020,1,7]],"date-time":"2020-01-07T17:59:33Z","timestamp":1578419973000},"page":"466-474","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":96,"title":["Neurodevelopmental, behavioral, and emotional symptoms common in Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4902-2425","authenticated-orcid":false,"given":"Andrew J.","family":"Darmahkasih","sequence":"first","affiliation":[{"name":"Pediatric Residency Program University of California, Irvine\/Children's Hospital of Orange County  Orange 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