{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T07:51:28Z","timestamp":1791273088657,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T00:00:00Z","timestamp":1581120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004794","name":"Centre National de la Recherche Scientifique","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Fat infiltration in individual muscles of sporadic inclusion body myositis (sIBM) patients has rarely been assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixteen sIBM patients were assessed using MRI of the thighs and lower legs (LL). The severity of fat infiltration, proximal\u2010to\u2010distal and side asymmetries, and the correlations with clinical and functional parameters were investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All the patients had fat\u2010infiltrated muscles, and thighs were more severely affected than LL. A proximal\u2010to\u2010distal gradient of fat infiltration was mainly observed for adductors, quadriceps, sartorius, and medial gastrocnemius muscles. A strong negative correlation was observed between the whole muscle fat fraction in the thighs and LL and the Inclusion Body Myositis Functional Rating Scale and Medical Research Council scores for the lower limbs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fat infiltration in individual muscles of sIBM patients is heterogeneous in terms of proximal\u2010to\u2010distal gradient and severity was correlated with clinical scores. These results should be considered for both natural history investigation and clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26813","type":"journal-article","created":{"date-parts":[[2020,1,18]],"date-time":"2020-01-18T05:25:12Z","timestamp":1579325112000},"page":"496-503","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Quantitative muscle MRI study of patients with sporadic inclusion body myositis"],"prefix":"10.1002","volume":"61","author":[{"given":"Behnaz","family":"Ansari","sequence":"first","affiliation":[{"name":"Centre de r\u00e9f\u00e9rence PACA R\u00e9union Rh\u00f4ne Alpes La Timone University Hospital, Aix\u2010Marseille University  Marseille"},{"name":"Aix\u2010Marseille University Centre de R\u00e9sonance Magn\u00e9tique Biologique et M\u00e9dicale  UMR CNRS Marseille France"},{"name":"Isfahan Neurosciences Research Center, Alzahra Research Institute Isfahan University of Medical 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