{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T13:42:33Z","timestamp":1790516553799,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002426","name":"Fondazione Telethon","doi-asserted-by":"publisher","award":["GUP15014 2015, Italy"],"award-info":[{"award-number":["GUP15014 2015, Italy"]}],"id":[{"id":"10.13039\/501100002426","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>We aimed to investigate the correlation between body composition (BC) and spinal muscular atrophy (SMA)\u2010specific motor function assessments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients with SMA types I or II, aged 1 to 10\u2009years, were recruited in this cross\u2010sectional study. The protocol included anthropometric measurements, and dual\u2010energy X\u2010ray absoprtiometry to assess fat mass (FM), lean mass (LM), fat\u2010free mass (FFM), FM and FFM indexes (FMI, FFMI), and motor function assessments (Children's Hospital of Philadelphia Infant Test of Neuromuscular Disorders scale for SMAI, and Hammersmith Functional Motor Scale\u2015Expanded for SMAII).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Eighty\u2010eight children were included. All had a higher FM percentage than reference values. Motor function was moderately correlated with body mass index (BMI), FFMI, and LMI in SMAI, and weakly correlated with FFMI, LMI, and LM:FM ratio in SMAII.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>BC shows promise as a potential biomarker for SMA, but further studies are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26823","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T20:41:58Z","timestamp":1580762518000},"page":"530-534","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Evaluation of body composition as a potential biomarker in spinal muscular atrophy"],"prefix":"10.1002","volume":"61","author":[{"given":"Giovanni","family":"Baranello","sequence":"first","affiliation":[{"name":"Developmental Neurology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"},{"name":"The Dubowitz Neuromuscular Centre, UCL NIHR GOSH Biomedical Research Centre UCL Great Ormond Street Institute of Child Health  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramona","family":"De Amicis","sequence":"additional","affiliation":[{"name":"International Center for the Assessment of Nutritional Status, Department of Food Environmental and Nutritional Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Teresa","family":"Arnoldi","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Zanin","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Mastella","sequence":"additional","affiliation":[{"name":"SAPRE\u2010UONPIA Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Riccardo","family":"Masson","sequence":"additional","affiliation":[{"name":"Developmental Neurology Unit Fondazione IRCCS Istituto Neurologico Carlo Besta  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Leone","sequence":"additional","affiliation":[{"name":"International Center for the Assessment of Nutritional Status, Department of Food Environmental and Nutritional Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia","family":"Alberti","sequence":"additional","affiliation":[{"name":"SAPRE\u2010UONPIA Fondazione IRCCS Ca\u2019 Granda Ospedale Maggiore Policlinico  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Foppiani","sequence":"additional","affiliation":[{"name":"International Center for the Assessment of Nutritional Status, Department of Food Environmental and Nutritional Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Battezzati","sequence":"additional","affiliation":[{"name":"International Center for the Assessment of Nutritional Status, Department of Food Environmental and Nutritional Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simona","family":"Bertoli","sequence":"additional","affiliation":[{"name":"International Center for the Assessment of Nutritional Status, Department of Food Environmental and Nutritional Sciences University of Milan  Milan Italy"},{"name":"Obesity Unit and Laboratory of Nutrition and Obesity Research Department of Endocrine and Metabolic Diseases, IRCCS Istituto Auxologico Italiano  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1702752"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1710504"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND-180327"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpf.12152"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2011.11.007"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2016.10.020"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41430-019-0392-2"},{"key":"e_1_2_9_9_1","first-page":"1","volume-title":"2000 CDC Growth Charts for the United States: Methods and Development. 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