{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T21:31:11Z","timestamp":1790285471887,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T00:00:00Z","timestamp":1581897600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Muscle MRI is of increasing importance for neuromuscular patients to detect changes in muscle volume, fat\u2010infiltration, and edema. We developed a method for semi\u2010automated segmentation of muscle MRI datasets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>An active contour\u2010evolution algorithm implemented within the ITK\u2010SNAP software was used to segment T1\u2010weighted MRI, and to quantify muscle volumes of neuromuscular patients (n = 65).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Semi\u2010automated compared with manual segmentation was shown to be accurate and time\u2010efficient. Muscle volumes and ratios of thigh\/lower leg volume were lower in myopathy patients than in controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). We found a decrease of lower leg muscle volume in neuropathy patients compared with controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01), which correlated with clinical parameters. In myopathy patients, muscle volume showed a positive correlation with muscle strength (r<jats:sub>left<\/jats:sub> = 0.79, p<jats:sub>left<\/jats:sub>\u2009&lt;\u2009.0001). Muscle volumes were independent of body mass index and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our method allows for exact and time\u2010efficient quantification of muscle volumes with possible use as a biomarker in neuromuscular patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26827","type":"journal-article","created":{"date-parts":[[2020,2,5]],"date-time":"2020-02-05T11:43:01Z","timestamp":1580902981000},"page":"600-607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Semi\u2010automated volumetry of MRI serves as a biomarker in neuromuscular patients"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1142-9633","authenticated-orcid":false,"given":"Madlaine","family":"M\u00fcller","sequence":"first","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maike F.","family":"Dohrn","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandro","family":"Romanzetti","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gadermayr","sequence":"additional","affiliation":[{"name":"Institute of Imaging and Computer Vision RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathrin","family":"Reetz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nils A.","family":"Kr\u00e4mer","sequence":"additional","affiliation":[{"name":"Clinic for Diagnostic and Interventional Radiology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christiane","family":"Kuhl","sequence":"additional","affiliation":[{"name":"Clinic for Diagnostic and Interventional Radiology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J\u00f6rg B.","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"},{"name":"JARA\u2010BRAIN Institute Molecular Neuroscience and Neuroimaging RWTH Aachen University  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Burkhard","family":"Gess","sequence":"additional","affiliation":[{"name":"Department of Neurology University Hospital Aachen  Aachen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00242-2"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-010-1799-2"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmri.20804"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(11)70025-4"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2010.08.001"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000364"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.10091547"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0070993"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000919"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0090377"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crad.2006.08.012"},{"issue":"3","key":"e_1_2_9_13_1","first-page":"151","article-title":"Multi\u2010slice MRI reveals heterogeneity in disease distribution along the length of muscle in Duchenne muscular dystrophy","volume":"36","author":"Chrzanowski SM","year":"2017","journal-title":"Acta Myol."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00320-8"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2018-320198"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.06.748"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.06.011"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2016.12.025"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802395-2.00031-6"},{"key":"e_1_2_9_20_1","volume-title":"Aids to the Examination of the Peripheral Nervous System; 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