{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T12:59:36Z","timestamp":1770296376716,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,15]],"date-time":"2020-02-15T00:00:00Z","timestamp":1581724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Herein we report a case of sporadic inclusion\u2010body myositis (sIBM) occurring at an unusually young age in a patient with primary Sj\u00f6gren syndrome, and use the case to explore possible shared mechanisms for disease susceptibility. Possible factors may include the association of both conditions with the 8.1 ancestral haplotype; the presence of anti\u2010cN1A antibodies, which, although considered specific for sIBM, are also seen in pSS; and the shared association with T\u2010cell large granular lymphocyte leukemia (T\u2010LGLL). Further evaluation of this patient did in fact reveal underlying T\u2010LGLL and mechanisms by which T cells in sIBM may escape immune regulation and contribute to disease phenotype are explored. Despite myofiber infiltration with CD8\u2010positive T cells in sIBM, and, although sIBM is traditionally considered treatment\u2010refractory, we report a significant response to the anti\u2010CD20 monoclonal antibody, rituximab, and discuss possible mechanisms by which this response may be mediated.<\/jats:p>","DOI":"10.1002\/mus.26830","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T17:25:08Z","timestamp":1581182708000},"page":"570-574","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Inclusion\u2010body myositis and primary Sj\u00f6gren syndrome: mechanisms for shared etiologies"],"prefix":"10.1002","volume":"61","author":[{"given":"Vidya S.","family":"Limaye","sequence":"first","affiliation":[{"name":"Rheumatology Department Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Cash","sequence":"additional","affiliation":[{"name":"Anatomical Pathology SA Pathology  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Caroline","family":"Smith","sequence":"additional","affiliation":[{"name":"Anatomical Pathology SA Pathology  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Koszyca","sequence":"additional","affiliation":[{"name":"Anatomical Pathology SA Pathology  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandy","family":"Patel","sequence":"additional","affiliation":[{"name":"Radiology Department Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven A.","family":"Greenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Brigham and Women's Hospital  Boston Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pravin","family":"Hissaria","sequence":"additional","affiliation":[{"name":"Immunology Department Royal Adelaide Hospital  Adelaide South Australia Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22052"},{"key":"e_1_2_7_3_1","doi-asserted-by":"crossref","unstructured":"VerstappenGM KroeseFG BootsmaH. T cells in primary Sjogren's syndrome: targets for early intervention.Rheumatology.https:\/\/doi.org\/10.1093\/rheumatology\/kez004.","DOI":"10.1093\/rheumatology\/kez004"},{"key":"e_1_2_7_4_1","first-page":"649","article-title":"Myositis in primary Sjogren's syndrome. Report of 3 cases","volume":"21","author":"Kraus A","year":"1994","journal-title":"J Rheumatol."},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2011.03.016"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-019-04411-8"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24989"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24199"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/BOR.0000000000000327"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-019-0186-x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0020266"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01200"},{"key":"e_1_2_7_13_1","first-page":"457","article-title":"Myositis in primary Sjogren's syndrome: data from a multicentre cohort","volume":"33","author":"Colafrancesca S","year":"2015","journal-title":"Clin Exp Rheum."},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/41.4.440"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-012-2556-4"},{"key":"e_1_2_7_16_1","first-page":"717","article-title":"Subclinical myositis is common in primary Sj\u00f6gren's syndrome and is not related to muscle pain","volume":"29","author":"Lindvall B","year":"2002","journal-title":"J Rheumatol."},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10570"},{"key":"e_1_2_7_18_1","first-page":"1871","article-title":"Inclusion body myositis","volume":"22","author":"Greenberg SA","year":"2016","journal-title":"Continuum (Minneap Minn)."},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/aww024"},{"key":"e_1_2_7_20_1","first-page":"2551","article-title":"Sj\u00f6gren's syndrome associated T cell large granular lymphocyte leukemia: a possible common etiopathogenesis","volume":"28","author":"Molad Y","year":"2001","journal-title":"J Rheumatol."},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000314900"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2005.07.001"},{"key":"e_1_2_7_23_1","doi-asserted-by":"crossref","unstructured":"BanoA PeraA AlmoukayedA et al. CD28nullCD4 T\u2010cell expansions in autoimmune disease suggest a link with cytomegalovirus infection.F1000 Res. 2019 Mar 25;8. pii: F1000 Faculty Rev\u2010327.https:\/\/doi.org\/10.12688\/f1000research.17119.1. eCollection2019.","DOI":"10.12688\/f1000research.17119.1"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.10.6514"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.27665"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000187124.92826.20"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcp.14102"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50029-y"},{"key":"e_1_2_7_29_1","first-page":"7506542","article-title":"Large granular lymphocytic leukemia: a report of response to rituximab","volume":"2017","author":"Ibrahim U","year":"2017","journal-title":"Case Rep Hematol."},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-009-1367-9"}],"updated-by":[{"DOI":"10.1002\/mus.27002","type":"erratum","label":"Erratum","source":"publisher","updated":{"date-parts":[[2020,6,23]],"date-time":"2020-06-23T00:00:00Z","timestamp":1592870400000}}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fmus.26830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26830","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.26830","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.26830","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T15:29:31Z","timestamp":1694100571000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.26830"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,15]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1002\/mus.26830"],"URL":"https:\/\/doi.org\/10.1002\/mus.26830","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,15]]},"assertion":[{"value":"2019-07-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}