{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T19:59:07Z","timestamp":1780084747160,"version":"3.54.0"},"reference-count":30,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,7]],"date-time":"2020-03-07T00:00:00Z","timestamp":1583539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Limb contractures are debilitating complications associated with various muscle and nervous system disorders. This report summarizes presentations at a conference at the Shirley Ryan AbilityLab in Chicago, Illinois, on April 19\u201320, 2018, involving researchers and physicians from diverse disciplines who convened to discuss current clinical and preclinical understanding of contractures in Duchenne muscular dystrophy, stroke, cerebral palsy, and other conditions. Presenters described changes in muscle architecture, activation, extracellular matrix, satellite cells, and muscle fiber sarcomeric structure that accompany or predispose muscles to contracture. Participants identified ongoing and future research directions that may lead to understanding of the intersecting factors that trigger contractures. These include additional studies of changes in muscle, tendon, joint, and neuronal tissues during contracture development with imaging, molecular, and physiologic approaches. Participants identified the requirement for improved biomarkers and outcome measures to identify patients likely to develop contractures and to accurately measure efficacy of treatments currently available and under development.<\/jats:p>","DOI":"10.1002\/mus.26845","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T14:54:18Z","timestamp":1582901658000},"page":"740-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Conference report on contractures in musculoskeletal and neurological conditions"],"prefix":"10.1002","volume":"61","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7466-6433","authenticated-orcid":false,"given":"Glen H.","family":"Nuckolls","sequence":"first","affiliation":[{"name":"Division of Neuroscience National Institute of Neurological Disorders and Stroke  Bethesda Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathi","family":"Kinnett","sequence":"additional","affiliation":[{"name":"Parent Project Muscular Dystrophy  Hackensack New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sudarshan","family":"Dayanidhi","sequence":"additional","affiliation":[{"name":"The Shirley Ryan AbilityLab  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea A.","family":"Domenighetti","sequence":"additional","affiliation":[{"name":"The Shirley Ryan AbilityLab  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina","family":"Duong","sequence":"additional","affiliation":[{"name":"Department of Neurology Stanford University  Palo Alto California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yetrib","family":"Hathout","sequence":"additional","affiliation":[{"name":"School of Pharmacy and Pharmaceutical Sciences Binghamton University  Johnson City New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"Lawlor","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine Medical College of Wisconsin  Milwaukee Wisconsin"},{"name":"Neuroscience Research Center Medical College of Wisconsin  Milwaukee Wisconsin"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina S. M.","family":"Lee","sequence":"additional","affiliation":[{"name":"Physical Therapy and Human Movement Sciences Northwestern University Feinberg School of Medicine  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. Peter","family":"Magnusson","sequence":"additional","affiliation":[{"name":"Department of Physical and Occupational Therapy Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"},{"name":"Institute of Sports Medicine Copenhagen, Bispebjerg Hospital  Copenhagen Denmark"},{"name":"Department of Orthopedic Surgery Bispebjerg and Frederiksberg Hospital  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Craig M.","family":"McDonald","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine &amp; Rehabilitation University of California Davis School of Medicine  Sacramento California"},{"name":"Department of Pediatrics University of California Davis School of Medicine  Sacramento California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth M.","family":"McNally","sequence":"additional","affiliation":[{"name":"Center for Genetic Medicine Northwestern University Feinberg School of Medicine  Chicago 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