{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T22:05:03Z","timestamp":1791669903630,"version":"4.3.4"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,16]],"date-time":"2020-03-16T00:00:00Z","timestamp":1584316800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001266","name":"Action Duchenne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001266","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Recombinant human insulin\u2010like growth factor\u20101 (rhIGF\u20101) is a growth factor and has anabolic effects on muscle. We investigated whether rhIGF\u20101 therapy: 1) improves or preserves muscle function; and 2) improves growth in boys with Duchenne muscular dystrophy (DMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study we compared prepubescent, ambulatory, glucocorticoid\u2010treated boys with DMD (n = 17) vs controls (glucocorticoid therapy only, n = 21) in a 6\u2010month\u2010long, prospective, randomized, controlled trial of subcutaneous rhIGF\u20101 therapy. The primary outcome was 6\u2010minute walk distance (6MWD). Secondary outcomes included height velocity (HV), change in height standard deviation score (\u0394HtSDS), motor function, cardiopulmonary function, body composition, insulin sensitivity, quality of life, and safety.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Change in 6MWD was similar between groups (rhIGF\u20101 vs controls [mean \u00b1\u2009SD]: 3.4\u2009\u00b1\u200932.4 vs \u22125.1\u2009\u00b1\u200950.2 meters, <jats:italic>P<\/jats:italic> = .53). Treated subjects grew more than controls (HV: 6.5\u2009\u00b1\u20091.7 vs 3.3\u2009\u00b1\u20091.3\u2009cm\/year, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001; 6\u2010month \u0394HtSDS: 0.25, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.0001). Lean mass and insulin sensitivity increased in treated subjects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>In boys with DMD, 6\u2009months of rhIGF\u20101 therapy did not change motor function, but it improved linear growth.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26846","type":"journal-article","created":{"date-parts":[[2020,2,28]],"date-time":"2020-02-28T14:38:51Z","timestamp":1582900731000},"page":"623-631","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Recombinant human insulin\u2010like growth factor\u20101 therapy for 6\u2009months improves growth but not motor function in boys with Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"61","author":[{"given":"Meilan M.","family":"Rutter","sequence":"first","affiliation":[{"name":"Division of Endocrinology Cincinnati Children's Hospital Medical Center  Cincinnati Ohio 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