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We also studied whether concentric contractions before or after eccentric contractions reduced muscle damage in dysferlin\u2010deficient mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After 12\u2009weeks of concentric training, there was no net gain in contractile force in dysferlin\u2010sufficient or dysferlin\u2010deficient mice, whereas eccentric training produced a net gain in force in both mouse strains. However, eccentric training induced more muscle damage in dysferlin\u2010deficient vs dysferlin\u2010sufficient mice. Although concentric training produced minimal muscle damage in dysferlin\u2010deficient mice, it still led to a prominent increase in centrally nucleated fibers. Previous exposure to concentric contractions conferred slight protection on dysferlin\u2010deficient muscle against damage from subsequent injurious eccentric contractions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Concentric contractions may help dysferlin\u2010deficient muscle derive the benefits of exercise without inducing damage.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26906","type":"journal-article","created":{"date-parts":[[2020,5,4]],"date-time":"2020-05-04T05:20:20Z","timestamp":1588569620000},"page":"393-403","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The effects of concentric and eccentric training in murine models of dysferlin\u2010associated muscular dystrophy"],"prefix":"10.1002","volume":"62","author":[{"given":"Morium","family":"Begam","sequence":"first","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renuka","family":"Roche","sequence":"additional","affiliation":[{"name":"Occupational Therapy Program, College of Health and Human Services Eastern Michigan University  Ypsilanti Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua J.","family":"Hass","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chantel A.","family":"Basel","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob M.","family":"Blackmer","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmine T.","family":"Konja","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber L.","family":"Samojedny","sequence":"additional","affiliation":[{"name":"Physical Therapy Program, Department of Health Care Sciences, Eugene Applebaum College of Pharmacy and Health Sciences Wayne State University  Detroit Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alyssa F.","family":"Collier","sequence":"additional","affiliation":[{"name":"Rehabilitation Department Emory University Hospital  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujay S.","family":"Galen","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Byrdine F. 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