{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T03:09:12Z","timestamp":1790824152626,"version":"4.1.0"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,6,21]],"date-time":"2020-06-21T00:00:00Z","timestamp":1592697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Phospholipids are essential components of cellular membranes and are closely associated with cellular functions, but relationships involving skeletal muscle phospholipid profiles and their physiological phenotypes have remained unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We carried out comprehensive phospholipid analyses using liquid chromatography\u2013tandem mass spectrometry to determine the phospholipid profiles of skeletal muscles derived from muscle\u2010wasting mouse models, including denervated and Duchenne muscular dystrophy mouse models (<jats:italic>mdx<\/jats:italic>) as well as rescued <jats:italic>mdx<\/jats:italic> mice expressing truncated dystrophin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Consistent phosphatidylcholine and phosphatidylethanolamine alterations in skeletal muscles isolated from denervated and <jats:italic>mdx<\/jats:italic> mice were observed. Notably, the levels of these phospholipids binding polyunsaturated fatty acids were reduced in denervated and <jats:italic>mdx<\/jats:italic> muscles. Moreover, rescuing the <jats:italic>mdx<\/jats:italic> pathology by expressing truncated dystrophin led to the restoration of phospholipid profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings support the hypothesis that phospholipid profiles of the skeletal muscle may be associated with skeletal muscle function.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.26993","type":"journal-article","created":{"date-parts":[[2020,6,4]],"date-time":"2020-06-04T12:49:54Z","timestamp":1591274994000},"page":"413-418","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Glycerophospholipid profile alterations are associated with murine muscle\u2010wasting phenotype"],"prefix":"10.1002","volume":"62","author":[{"given":"Nanami","family":"Senoo","sequence":"first","affiliation":[{"name":"Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences University of Shizuoka  Shizuoka Japan"},{"name":"Department of Physiology Johns Hopkins University School of Medicine  Baltimore Maryland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noriyuki","family":"Miyoshi","sequence":"additional","affiliation":[{"name":"Laboratory of Biochemistry, Graduate School of Nutritional and Environmental Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihito","family":"Morita","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Tanihata","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience National Center for Neurology and Psychiatry  Kodaira Tokyo Japan"},{"name":"Department of Cell Physiology Jikei University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin'ichi","family":"Takeda","sequence":"additional","affiliation":[{"name":"Department of Molecular Therapy, National Institute of Neuroscience National Center for Neurology and Psychiatry  Kodaira Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8806-9763","authenticated-orcid":false,"given":"Shinji","family":"Miura","sequence":"additional","affiliation":[{"name":"Laboratory of Nutritional Biochemistry, Graduate School of Nutritional and Environmental Sciences University of Shizuoka  Shizuoka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2015.03.004"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2013.05.016"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2011.10.019"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1255\/ejms.671"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2009.07.013"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/76.6.1222"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/126.3.653"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/123.3.512"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clnu.2012.11.013"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201801857RRR"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.09.039"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1194\/jlr.M060533"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2005.06.005"},{"key":"e_1_2_9_15_1","unstructured":"WarnersGR BalkerB BonebakkerL et al. gplots: Various R programming tools for plotting data. 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