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With the lack of a diagnostic biomarker, the diagnosis relies on clinical suspicion, clinical findings, and the demonstration of demyelinating changes on electrodiagnostic (EDx) testing and nerve pathology. As a result, patients can often be misdiagnosed with CIDP and unnecessarily treated with immunotherapy. Interpreting the EDx testing and cerebrospinal fluid findings in light of the clinical phenotype, recognizing atypical forms of CIDP, and screening for CIDP mimickers are the mainstays of the approach to patients suspected of having CIDP, and are detailed in this review. We also review the currently available treatment options, including intravenous immunoglobulin (IVIg), corticosteroids (CCS), and plasma exchange (PE), and discuss how to approach treatment\u2010refractory cases. Finally, we emphasize the need to adopt objective outcome measures to monitor treatment response.<\/jats:p>","DOI":"10.1002\/mus.27046","type":"journal-article","created":{"date-parts":[[2020,9,23]],"date-time":"2020-09-23T07:21:29Z","timestamp":1600845689000},"page":"157-169","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":80,"title":["Chronic inflammatory demyelinating polyradiculoneuropathy\u2014Diagnostic pitfalls and treatment approach"],"prefix":"10.1002","volume":"63","author":[{"given":"Amro M.","family":"Stino","sequence":"first","affiliation":[{"name":"Division of Neuromuscular Medicine, Department of Neurology University of Michigan School of Medicine  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elie","family":"Naddaf","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Dyck","sequence":"additional","affiliation":[{"name":"Department of Neurology, Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0212-8254","authenticated-orcid":false,"given":"P. 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