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Acute\u2010onset autonomic neuropathies manifest with such conditions as paraneoplastic syndromes, Guillain\u2010Barre syndrome, Sj\u00f6gren syndrome, infection, or toxins\/chemotherapy. When the presentation is acute, immune\u2010mediated, and without a secondary cause, autoimmune autonomic ganglionopathy is likely, and should be considered for immunotherapy. Of the chronic\u2010onset forms, diabetes is the most widespread and disabling, with autonomic impairment portending increased mortality and cardiac wall remodeling risk. Acquired light chain (AL) and transthyretin (TTR) amyloidosis represent two other key etiologies, with TTR amyloidosis now amenable to newly\u2010approved gene\u2010modifying therapies. The COMPASS\u201031 questionnaire is a validated outcome measure that can be used to monitor autonomic severity and track treatment response. Symptomatic treatments targeting orthostatic hypotension, among other symptoms, should be individualized and complement disease\u2010modifying therapy, when possible.<\/jats:p>","DOI":"10.1002\/mus.27048","type":"journal-article","created":{"date-parts":[[2020,9,25]],"date-time":"2020-09-25T16:15:29Z","timestamp":1601050529000},"page":"10-21","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":64,"title":["Autonomic neuropathies"],"prefix":"10.1002","volume":"63","author":[{"given":"Divpreet","family":"Kaur","sequence":"first","affiliation":[{"name":"Department of Neurology Penn State College of Medicine  Hershey Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harmanpreet","family":"Tiwana","sequence":"additional","affiliation":[{"name":"Department of Neurology Dartmouth\u2010Hitchcok Medical Center  Lebanon New Hampshire 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