{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T21:59:47Z","timestamp":1776290387322,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Idiopathic small fiber neuropathy (iSFN) lacks broadly accepted diagnostic criteria, which hinders its timely diagnosis and treatment. A systematic literature review was performed to assess the published screening and diagnostic criteria for iSFN, excluding studies where SFN was of well\u2010established etiology. Eighty\u2010four clinical studies and seven guideline\/review publications were included in this systematic review. Substantial heterogeneity existed in iSFN diagnostic criteria. The most common set of criteria to diagnose iSFN [presence of any symptoms of iSFN, absence of large fiber involvement, and reduced intraepidermal nerve fiber density (IENFD)] was used in only 14% of studies. Mandatory individual criteria to confirm iSFN included any sensory symptoms (60% of studies), pain (19% of studies), small fiber signs (20% of studies), absence of large fiber signs (62% of studies), reduced IENFD (38% of studies), and autonomic symptoms (1% of studies). This review highlights a clear need for standardized, evidence\u2010based guidelines for diagnosing iSFN.<\/jats:p>","DOI":"10.1002\/mus.27070","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T08:28:45Z","timestamp":1601368125000},"page":"170-177","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Diagnostic criteria for idiopathic small fiber neuropathy: A systematic review"],"prefix":"10.1002","volume":"63","author":[{"given":"Simon","family":"Haroutounian","sequence":"first","affiliation":[{"name":"Washington University Pain Center and Division of Clinical and Translational Research, Department of Anesthesiology Washington University in St Louis School of Medicine  St Louis Missouri USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marko S.","family":"Todorovic","sequence":"additional","affiliation":[{"name":"Washington University Pain Center and Division of 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