{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,26]],"date-time":"2025-05-26T14:28:31Z","timestamp":1748269711180,"version":"3.40.5"},"reference-count":41,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T00:00:00Z","timestamp":1601337600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Antibodies against ganglioside complexes (GSCs) are associated with various clinical features and subtypes of Guillain\u2010Barr\u00e9 syndrome (GBS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>One\u2010hundred patients were evaluated for antibodies to GSCs formed by combination of GM1, GM2, GD1a, GD1b, GT1b, and GQ1b using manual enzyme linked immuno\u2010sorbent assay (ELISA).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010six patients were GSC antibody\u2010positive, most frequent being against GM1\u2010containing GSC (76.9%). Gender distribution, mean age, symptom\u2010duration, antecedent events, electrophysiological subtypes, requirement for mechanical ventilation, and median duration of hospital stay were comparable between the GSC antibody\u2010positive and negative groups. There was no association between specific GSC antibody and electrophysiological subtypes or clinical variants. After controlling for false discovery rate (FDR) using the Benjamini\u2010Hochberg method, the number of subjects who improved in overall disability sum score, modified Erasmus GBS outcome score, and neuropathy symptom score at discharge was significantly higher in the GSC antibody\u2010positive group. Improvements in Medical Research Council sum scores and Hughes Disability Scale during the hospital stay between the GSC antibody\u2010positive and negative groups were not significantly different after controlling for FDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The GSC antibody\u2010positive group had better outcome at hospital discharge in some of the disability scores. Pathophysiological pathways among patients without GSC antibodies may be different and this requires further evaluation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27071","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T06:53:15Z","timestamp":1600325595000},"page":"728-734","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Ganglioside complex antibodies in an Indian cohort of Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"62","author":[{"given":"Rahul","family":"Wahatule","sequence":"first","affiliation":[{"name":"Department of Neurology National Institute of Mental Health and Neurosciences (NIMHANS) Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5698-3067","authenticated-orcid":false,"given":"Debprasad","family":"Dutta","sequence":"additional","affiliation":[{"name":"Department of Human Genetics 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