{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T03:56:22Z","timestamp":1784260582673,"version":"3.55.0"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,7]],"date-time":"2020-10-07T00:00:00Z","timestamp":1602028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Smooth muscle dysfunction in Duchenne muscular dystrophy (DMD) has been rarely studied. A cross\u2010sectional study was conducted to estimate the prevalence of smooth muscle dysfunction (vascular, upper gastrointestinal, and bladder smooth muscle) in children with DMD using questionnaires (Pediatric Bleeding Questionnaire, Pediatric Gastroesophageal Symptom Questionnaire, and Dysfunctional Voiding Symptom Score). Investigations included bleeding time estimation, nuclear scintigraphy for gastroesophageal reflux, and uroflowmetry for urodynamic abnormalities. Ninety\u2010nine subjects were included in the study. The prevalence of vascular, upper gastrointestinal, and bladder smooth muscle dysfunction was 27.2%. Mean bleeding time was prolonged by 117.5\u2009seconds. The prevalence of gastroesophageal reflux was 21%. Voided volume\/estimated bladder capacity over 15% and abnormal flow curves on uroflowmetry were seen in 18.2% and 9.7% of the subjects, respectively. Our study highlights the need for addressing issues related to smooth muscle dysfunction in the routine clinical care of patients with DMD.<\/jats:p>","DOI":"10.1002\/mus.27077","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T20:21:40Z","timestamp":1601583700000},"page":"699-704","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Prevalence of smooth muscle dysfunction among children with Duchenne muscular dystrophy"],"prefix":"10.1002","volume":"62","author":[{"given":"Ranjith K.","family":"Manokaran","sequence":"first","affiliation":[{"name":"Center of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences New Delhi India"},{"name":"Division of Pediatric Neurology, Department of Neurology Sri Ramachandra Institute of Higher Education Chennai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Aggarwala","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rakesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arun K.","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiology All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Biswaroop","family":"Chakrabarty","sequence":"additional","affiliation":[{"name":"Center of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Jauhari","sequence":"additional","affiliation":[{"name":"Center of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravindra M.","family":"Pandey","sequence":"additional","affiliation":[{"name":"Department of Biostatistics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheffali","family":"Gulati","sequence":"additional","affiliation":[{"name":"Center of Excellence and Advanced Research on Childhood Neurodevelopmental Disorders, Child Neurology Division, Department of Pediatrics All India Institute of Medical Sciences New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,7]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.23528"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/ejhg.2012.301"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0102737"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(89)90157-3"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(88)90191-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/01202412-199907000-00015"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2005.05.005"},{"key":"e_1_2_10_9_1","first-page":"742","article-title":"Symptoms of upper gastrointestinal dysfunction in Duchenne muscular dystrophy: a case\u2010control study","volume":"71","author":"Jaffe KM","year":"1990","journal-title":"Arch Phys Med Rehabil."},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2005.41303.x"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1007\/s13312-015-0566-5","article-title":"Revised IAP growth charts for height, weight, and body mass index for 5\u2010 to 18\u2010year\u2010old Indian children","volume":"52","author":"Indian Academy of Pediatrics Growth Charts Committee","year":"2015","journal-title":"Indian Pediatr."},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1983.03340090066032"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1097\/00043426-199502000-00004","article-title":"Bleeding time in normal children","volume":"17","author":"Aversa LA","year":"1995","journal-title":"J Pediatr Hematol Oncol."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i12.3619"},{"key":"e_1_2_10_15_1","unstructured":"HommaY.http:\/\/www.ics.org\/publications\/ici_2\/chapters\/chap07.pdf. 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