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Segregating these diagnoses is typically straightforward, but, when the two diseases co\u2010occur in the same individual, making a diagnosis of OMG can be very challenging. In this review we address what is known about the coexistence of OMG and thyroid eye disease and we highlight the clinical features that are suggestive of overlapping conditions. We also describe the major testing approaches used in the diagnosis of these two entities, with special emphasis on the potential shortcomings of individual tests in patients with overlapping disease. In patients with thyroid eye disease, securing a diagnosis of OMG may not be possible on the basis of a single positive test. A multimodal approach using clinical, serologic, imaging, and electrodiagnostic data, is typically required.<\/jats:p>","DOI":"10.1002\/mus.27118","type":"journal-article","created":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T06:57:35Z","timestamp":1606546655000},"page":"631-639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Challenges in diagnosing coexisting ocular myasthenia gravis and thyroid eye disease"],"prefix":"10.1002","volume":"63","author":[{"given":"Benjamin","family":"Claytor","sequence":"first","affiliation":[{"name":"Neuromuscular Center Neurological Institute, Cleveland Clinic  Cleveland Ohio USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4248-8927","authenticated-orcid":false,"given":"Yuebing","family":"Li","sequence":"additional","affiliation":[{"name":"Neuromuscular Center Neurological Institute, Cleveland Clinic  Cleveland Ohio 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