{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T23:49:55Z","timestamp":1789516195763,"version":"build-2803163510"},"reference-count":44,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,11,27]],"date-time":"2020-11-27T00:00:00Z","timestamp":1606435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K12\u2010HD055929"],"award-info":[{"award-number":["K12\u2010HD055929"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this study we explored walking activity in a large cohort of boys with Duchenne muscular dystrophy (DMD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Step activity (monitored for 7\u2009days), functional ability, and strength were quantified in ambulatory boys (5\u201012.9\u2009years of age) with DMD and unaffected boys. Ambulatory status was determined 2\u2009years later.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Two to 5\u2009days of activity monitoring predicted weekly step activity (adjusted <jats:italic>R<\/jats:italic><jats:sup>2<\/jats:sup> = 0.80\u20100.95). Age comparisons revealed significant declines for step activity with increasing age, and relationships were found between step activity with both function and strength (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01). Our regression model predicted 36.5% of the variance in step activity. Those who were still ambulatory after 2\u2009years demonstrated baseline step activity nearly double that of those who were no longer walking 2\u2009years later (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Step activity for DMD is related to and predictive of functional declines, which may be useful for clinical trials.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27119","type":"journal-article","created":{"date-parts":[[2020,11,14]],"date-time":"2020-11-14T11:45:06Z","timestamp":1605354306000},"page":"192-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Walking activity in a large cohort of boys with <scp>Duchenne<\/scp> muscular dystrophy"],"prefix":"10.1002","volume":"63","author":[{"given":"Donovan J.","family":"Lott","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; Health Professions  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Taivassalo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia R.","family":"Senesac","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; Health Professions  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca J.","family":"Willcocks","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; Health Professions  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ann M.","family":"Harrington","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Zilke","sequence":"additional","affiliation":[{"name":"Oregon Health &amp; Science University, Shriners Hospitals for Children  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilary","family":"Cunkle","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; Health Professions  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Powers","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; Health Professions  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika L.","family":"Finanger","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William D.","family":"Rooney","sequence":"additional","affiliation":[{"name":"Advanced Imaging Research Center, Oregon Health and Science University  Portland Oregon USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gihan I.","family":"Tennekoon","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy, Children's Hospital of Philadelphia  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Vandenborne","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida, College of Public Health &amp; 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