{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T09:18:54Z","timestamp":1769246334847,"version":"3.49.0"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,18]],"date-time":"2021-11-18T00:00:00Z","timestamp":1637193600000},"content-version":"am","delay-in-days":352,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH\u201016\u20101\u20100725"],"award-info":[{"award-number":["W81XWH\u201016\u20101\u20100725"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008321","name":"Pennsylvania State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Erythropoietin (EPO) promotes myelination and functional recovery in rodent peripheral nerve injury (PNI). While EPO receptors (<jats:italic>EpoR<\/jats:italic>) are present in Schwann cells, the role of <jats:italic>EpoR<\/jats:italic> in PNI recovery is unknown because of the lack of <jats:italic>EpoR<\/jats:italic> antagonists or Schwann cell\u2010specific <jats:italic>EpoR<\/jats:italic> knockout animals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using the <jats:italic>Cre\u2010loxP<\/jats:italic> system, we developed a myelin protein zero (Mpz) promoter\u2010driven knockout mouse model of Schwann cell <jats:italic>EpoR<\/jats:italic> (<jats:italic>MpzCre\u2010EpoR<\/jats:italic><jats:sup><jats:italic>flox\/flox<\/jats:italic><\/jats:sup>, <jats:italic>Mpz\u2010EpoR\u2010KO<\/jats:italic>). <jats:italic>Mpz\u2010EpoR\u2010KO<\/jats:italic> and control mice were assigned to sciatic nerve crush injury followed by EPO treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>EPO treatment significantly accelerated functional recovery in control mice in contrast to significantly reduced functional recovery in <jats:italic>Mpz\u2010EpoR\u2010KO<\/jats:italic> mice. Significant muscle atrophy was found in the injured hindlimb of EPO\u2010treated <jats:italic>Mpz\u2010EpoR\u2010KO<\/jats:italic> mice but not in EPO\u2010treated control mice.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These preliminary findings provide direct evidence for an obligatory role of Schwann\u2010cell specific <jats:italic>EpoR<\/jats:italic> for EPO\u2010induced functional recovery and muscle atrophy following PNI.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27121","type":"journal-article","created":{"date-parts":[[2020,11,18]],"date-time":"2020-11-18T17:01:43Z","timestamp":1605718903000},"page":"268-272","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Obligatory role of Schwann cell\u2010specific erythropoietin receptors in erythropoietin\u2010induced functional recovery and neurogenic muscle atrophy after nerve injury"],"prefix":"10.1002","volume":"63","author":[{"given":"M A Hassan","family":"Talukder","sequence":"first","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Il","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery Hanyang University Guri Hospital  Guri South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John P.","family":"Hegarty","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anagha A.","family":"Gurjar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary","family":"O'Brien","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zara","family":"Karuman","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grant D.","family":"Wandling","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8069-234X","authenticated-orcid":false,"given":"Prem Kumar","family":"Govindappa","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University College of Medicine  Hershey Pennsylvania USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4438-7118","authenticated-orcid":false,"given":"John C.","family":"Elfar","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics and Rehabilitation, Center for Orthopaedics and Translational Science The Pennsylvania State University 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