{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T07:30:32Z","timestamp":1792654232191,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,12,8]],"date-time":"2021-12-08T00:00:00Z","timestamp":1638921600000},"content-version":"am","delay-in-days":351,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#am"},{"start":{"date-parts":[[2020,12,22]],"date-time":"2020-12-22T00:00:00Z","timestamp":1608595200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["NIAMS R21 AR064949\u2010 01A1"],"award-info":[{"award-number":["NIAMS R21 AR064949\u2010 01A1"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000001","name":"National Science Foundation","doi-asserted-by":"publisher","award":["DMR\u20101157490 & DMR\u20101644779"],"award-info":[{"award-number":["DMR\u20101157490 & DMR\u20101644779"]}],"id":[{"id":"10.13039\/100000001","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000005","name":"U.S. Department of Defense","doi-asserted-by":"publisher","award":["W81XWH1910330"],"award-info":[{"award-number":["W81XWH1910330"]}],"id":[{"id":"10.13039\/100000005","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This two\u2010part study explored the safety, feasibility, and efficacy of a mild\u2013moderate resistance isometric leg exercise program in ambulatory boys with Duchenne muscular dystrophy (DMD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      First, we used a dose escalation paradigm with varying intensity and frequency of leg isometric exercise to determine the dose response and safety in 10 boys. Second, we examined safety and feasibility of a 12\u2010wk in\u2010home, remotely supervised, mild\u2013moderate intensity strengthening program in eight boys. Safety measures included T\n                      <jats:sub>2<\/jats:sub>\n                      MRI, creatine kinase levels, and pain. Peak strength and function (time to ascend\/descend four stairs) were also measured.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dose\u2010escalation revealed no signs of muscle damage. Seven of the eight boys completed the 12\u2010wk in\u2010home program with a compliance of 84.9%, no signs of muscle damage, and improvements in strength (knee extensors\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.01; knee flexors\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05) and function (descending steps\n                      <jats:italic>P<\/jats:italic>\n                      \u2009&lt;\u2009.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>An in\u2010home, mild\u2013moderate intensity leg exercise program is safe with potential to positively impact both strength and function in ambulatory boys with DMD.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.27137","type":"journal-article","created":{"date-parts":[[2020,12,9]],"date-time":"2020-12-09T23:57:35Z","timestamp":1607558255000},"page":"320-326","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Safety, feasibility, and efficacy of strengthening exercise in\n                    <scp>Duchenne<\/scp>\n                    muscular dystrophy"],"prefix":"10.1002","volume":"63","author":[{"given":"Donovan J.","family":"Lott","sequence":"first","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanja","family":"Taivassalo","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Korey D.","family":"Cooke","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyunjun","family":"Park","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zahra","family":"Moslemi","sequence":"additional","affiliation":[{"name":"Department of Applied Physiology &amp; Kinesiology University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhinandan","family":"Batra","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean C.","family":"Forbes","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barry J.","family":"Byrne","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Glenn A.","family":"Walter","sequence":"additional","affiliation":[{"name":"Department of Physiology and Functional Genomics University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krista","family":"Vandenborne","sequence":"additional","affiliation":[{"name":"Department of Physical Therapy University of Florida  Gainesville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1249\/MSS.0000000000001639"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23244"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00948.2018"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1139\/h2012-035"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"174","article-title":"Effect of exercise in Duchenne muscular dystrophy","volume":"67","author":"Scott OM","year":"1981","journal-title":"Physiotherapy"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1966.03110110067015"},{"issue":"1","key":"e_1_2_10_8_1","first-page":"26","article-title":"Effect on maximal strength of submaximal exercise in Duchenne muscular dystrophy","volume":"58","author":"Lateur BJ","year":"1979","journal-title":"Am J Phys Med"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1177\/1545968313496326"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00042752-199301000-00006"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-973007"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1999.87.6.2311"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00421-006-0199-4"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0838.2006.00525.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12234"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06129-8"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/sms.12880"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20398"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1152\/japplphysiol.00889.2005"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/mrm.20953"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21986"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1113\/expphysiol.2012.070722"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0194283"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpn.2013.09.005"},{"issue":"1","key":"e_1_2_10_25_1","first-page":"9","article-title":"Pain in children: comparison of assessment scales","volume":"14","author":"Wong DL","year":"1988","journal-title":"Pediatr Nurs"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000775"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2011.06.750"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2010.03.024"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0000000000000957"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/0031512517740684"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016721"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2017.10.016"},{"issue":"2","key":"e_1_2_10_33_1","first-page":"103","article-title":"Detection and identification of myoglobin in serum by immunoblotting. 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