{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T15:51:59Z","timestamp":1785340319576,"version":"3.55.0"},"reference-count":17,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,12,26]],"date-time":"2020-12-26T00:00:00Z","timestamp":1608940800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Diagnosing cervical radiculopathy (CR) can be difficult because of symptomatic overlap with peripheral neuropathies. In this retrospective observational study, we aimed to determine whether short\u2010tau inversion recovery (STIR) magnetic resonance imaging (MRI) sequences are useful for detecting signs of denervation in the multifidus muscles in patients with CR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We analyzed the data of 18 patients with CR who developed arm weakness within 1 year. We also included 10 patients with sensorimotor symptoms involving the upper extremities who did not have intervertebral foraminal stenosis on MRI as controls. For each patient with CR, the signal intensity (SI) of the affected multifidus muscles was measured and compared to that on the contralateral side (signal intensity ratio: SIR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Control patients without CR did not exhibit STIR signal abnormalities in the multifidus muscles. Most of the 18 patients with CR were male (83.3%), and the mean age was 59.4\u2009years. Thirteen of 18 CR patients (72.2%) were determined to have STIR signal abnormalities by a radiologist. The mean SIR in the 13 patients with increased SI was significantly higher than that in the five patients without signal abnormalities (1.23 vs 0.97, <jats:italic>P<\/jats:italic> = .004), supporting the radiologist's diagnosis. The distribution of signal abnormalities closely followed those identified via clinical and electrophysiological tests, especially severe weakness (<jats:italic>P<\/jats:italic> = .044).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Denervation edema of the multifidus muscles can be detected in CR and correlates with clinical\/electrophysiological tests and weakness severity, which may aid in CR diagnostics.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27142","type":"journal-article","created":{"date-parts":[[2020,12,13]],"date-time":"2020-12-13T08:41:02Z","timestamp":1607848862000},"page":"365-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnostic usefulness of denervation edema in the multifidus muscles using <scp>3\u2010T<\/scp>esla magnetic resonance imaging in cervical radiculopathy"],"prefix":"10.1002","volume":"63","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3951-4618","authenticated-orcid":false,"given":"Takeshi","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Neurology Chikamori Hospital  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shugo","family":"Suwazono","sequence":"additional","affiliation":[{"name":"Center for Clinical Neuroscience and Division of Neurology National Hospital Organization Okinawa National Hospital  Ginowan Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takeshi","family":"Sueyoshi","sequence":"additional","affiliation":[{"name":"Department of Radiology Minei Daiichi Hospital  Urasoe Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-5081","authenticated-orcid":false,"given":"Hiroyuki","family":"Nodera","sequence":"additional","affiliation":[{"name":"Department of Neurology Kanazawa Medical University  Uchinada Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,12,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.9734\/BJMMR\/2013\/3031"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24560"},{"key":"e_1_2_11_4_1","volume-title":"The Cervical Spine","author":"Benzel EC","year":"2012"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/PHM.0b013e3181b333a9"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.E.00704"},{"key":"e_1_2_11_7_1","volume-title":"Electromyography and Neuromuscular Disorders: Clinical\u2010Electrophysiologic Correlations","author":"Preston DC","year":"2012"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200009)23:9<1431::AID-MUS16>3.0.CO;2-P"},{"issue":"8","key":"e_1_2_11_9_1","first-page":"1427","article-title":"Sequential MR imaging of denervated muscle: experimental study","volume":"23","author":"Bendszus M","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.312105122"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.265055712"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.08.012"},{"issue":"2","key":"e_1_2_11_13_1","first-page":"383","article-title":"The human lumbar dorsal rami","volume":"134","author":"Bogduk N","year":"1982","journal-title":"J Anat"},{"issue":"8","key":"e_1_2_11_14_1","first-page":"483","article-title":"The lumbar multifidus muscle is polysegmentally innervated","volume":"40","author":"Wu PB","year":"2000","journal-title":"Electromyogr Clin Neurophysiol"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2012.244"},{"issue":"3","key":"e_1_2_11_16_1","first-page":"214","article-title":"Relationship between clinical and needle electromyography findings in patients with myotomal muscle weakness caused by cervical disk herniation: a long\u2010term follow\u2010up study","volume":"25","author":"Bahadir C","year":"2008","journal-title":"Trakya \u00dcniv T\u0131p Fak Derg"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh722"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199905)22:5<608::AID-MUS9>3.0.CO;2-L"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27142","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27142","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27142","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T05:20:18Z","timestamp":1693545618000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27142"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12,26]]},"references-count":17,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1002\/mus.27142"],"URL":"https:\/\/doi.org\/10.1002\/mus.27142","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,12,26]]},"assertion":[{"value":"2020-06-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}