{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T14:17:35Z","timestamp":1788617855936,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T00:00:00Z","timestamp":1613347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001321","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001321","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Thymectomy is required for the treatment of thymoma\u2010associated myasthenia gravis (MG). However, MG may develop only after thymectomy, a condition known as post\u2010thymectomy MG. This study aimed to investigate the risk factors for post\u2010thymectomy MG in patients with thymoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively identified 235 patients with thymoma who underwent thymectomy at a single hospital from January 2008 to December 2017: 44 with preoperatively diagnosed MG were excluded, leaving 191 patients in the final analysis. Univariable survival analyses using Cox proportional hazards regression model and Kaplan\u2010Meier estimate were conducted to identify risk factors for post\u2010thymectomy MG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Post\u2010thymectomy MG developed in 4.2% (8\/191) of the patients with thymoma between 18\u2009days and 108\u2009mo after surgery. Hazard ratios (HRs) of pre\u2010 and postoperative anti\u2010acetylcholine receptor antibody (AChR\u2010Ab) titers were 2.267 (<jats:italic>P<\/jats:italic> =\u2009.002) and 1.506 (<jats:italic>P<\/jats:italic> &lt;\u2009.001), respectively. Patients with extended thymectomy had a low chance of post\u2010thymectomy MG (HR 0.035, <jats:italic>P<\/jats:italic> =\u2009.007). Larger thymoma (HR, 1.359; <jats:italic>P<\/jats:italic> =\u2009.005) and type A or AB thymoma according to World Health Organization histological classification (HR, 11.92; <jats:italic>P<\/jats:italic> =\u2009.021) were associated with higher chances of post\u2010thymectomy MG. Within the subgroup of preoperatively AChR\u2010Ab seropositive patients, post\u2010thymectomy MG developed in 22.2% (6\/27).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pre\u2010 and postoperative AChR\u2010Ab levels should be measured in patients with thymoma. A large thymoma and partial thymectomy appear to be associated with a higher probability of post\u2010thymectomy MG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27169","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T09:10:44Z","timestamp":1610701844000},"page":"531-537","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk factors for developing post\u2010thymectomy myasthenia gravis in patients with thymoma"],"prefix":"10.1002","volume":"63","author":[{"given":"Ahwon","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seok\u2010Jin","family":"Choi","sequence":"additional","affiliation":[{"name":"Department of Neurology Inha University School of Medicine  Incheon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang Hyun","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Thoracic and Cardiovascular Surgery Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seonkyung","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Bundang Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyoshin","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin\u2010Ah","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Je\u2010Young","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sung\u2010Min","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoon\u2010Ho","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul Metropolitan Government Seoul National University Boramae Medical Center  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jung\u2010Joon","family":"Sung","sequence":"additional","affiliation":[{"name":"Department of Neurology Seoul National University Hospital  Seoul Republic of Korea"},{"name":"Department of Neurology Seoul National University College of Medicine  Seoul Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,15]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.144.3.739"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.05.040187.001545"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11748-007-0185-8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hoc.2008.03.004"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2008.07.012"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-198707000-00013"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4975(01)03080-6"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jocn.2010.05.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2008.04.070"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejcts.2005.03.039"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2014.10.068"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semtcvs.2018.02.027"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23944"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0114060"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.56.5.496"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000290"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezz001"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezw178"},{"key":"e_1_2_10_20_1","volume-title":"Pathology and Genetics of the Lung, Pleura, Thymus and Heart","author":"Travis WD","year":"2004"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1097\/JTO.0000000000000393"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2010.172"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14052"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/ejcts\/ezr268"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27169","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27169","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27169","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T04:09:22Z","timestamp":1693541362000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27169"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,15]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,4]]}},"alternative-id":["10.1002\/mus.27169"],"URL":"https:\/\/doi.org\/10.1002\/mus.27169","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,15]]},"assertion":[{"value":"2020-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}