{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,25]],"date-time":"2026-02-25T04:17:52Z","timestamp":1771993072715,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,1,24]],"date-time":"2021-01-24T00:00:00Z","timestamp":1611446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>We evaluated the functional consequences of diaphragm involvement in patients with inclusion body myositis (IBM).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ultrasound diaphragm thickening fraction (TFdi), lung function and dyspnea levels were compared between IBM patients and matched controls. Patients with IBM were grouped into \u201clow\u201d and \u201chigh\u201d diaphragm activity based on TFdi values (with cutoff value being the lowest observed TFdi in the control group), and clinical characteristics were compared between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>20 IBM patients were included. TFdi was significantly lower in patients and correlated with time since symptom onset (rho = 0.74, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Patients had significantly lower forced vital capacity and higher dyspnea scores than controls. IBM patients with \u201clow\u201d diaphragm activity (n = 9) had lower 6\u2010min walking distance, higher resting and exertional dyspnea and a larger positional decrease in vital capacity (all <jats:italic>P<\/jats:italic>\u2009\u2264\u2009.03) than patients with \u2018high\u2019 activity. Timed Up and Go time and St. George's Respiratory Questionnaire were not different between groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Diaphragm involvement in IBM is related to disease duration and has detrimental effects on lung function, dyspnea and exercise capacity. Further studies are required to investigate its potential as a therapeutic target.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27170","type":"journal-article","created":{"date-parts":[[2021,1,15]],"date-time":"2021-01-15T07:21:40Z","timestamp":1610695300000},"page":"497-505","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants and functional impacts of diaphragmatic involvement in patients with inclusion body myositis"],"prefix":"10.1002","volume":"63","author":[{"given":"Marie\u2010H\u00e9l\u00e8ne","family":"Leli\u00e8vre","sequence":"first","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Service de Pneumologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie","family":"Hudson","sequence":"additional","affiliation":[{"name":"Division of Rheumatology, Jewish General Hospital Lady Davis Institute for Medical Research and Department of Medecine, McGill University  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan A.","family":"Botez","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Service de Neurologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Centre de Recherche du Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CRCHUM) \u2013 Axe Neurosciences  Montr\u00e9al Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9855-9499","authenticated-orcid":false,"given":"Bruno\u2010Pierre","family":"Dub\u00e9","sequence":"additional","affiliation":[{"name":"D\u00e9partement de M\u00e9decine Service de Pneumologie, Centre Hospitalier de l'Universit\u00e9 de Montr\u00e9al (CHUM)  Montr\u00e9al Qu\u00e9bec Canada"},{"name":"Centre de Recherche du 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