{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T01:08:03Z","timestamp":1780448883923,"version":"3.54.1"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,2,2]],"date-time":"2021-02-02T00:00:00Z","timestamp":1612224000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The most common subtypes of Guillain\u2010Barr\u00e9 syndrome (GBS) are acute inflammatory demyelinating polyneuropathy (AIDP) and acute motor axonal neuropathy (AMAN). In the first days after the onset of weakness, standard nerve conduction studies (NCS) may not distinguish GBS subtypes. Reduced nerve excitability may be an early symptom of nerve dysfunction, which can be determined with the compound muscle action potential (CMAP) scan. The aim of this study was to explore whether early changes in motor nerve excitability in GBS patients are related to various subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prospective case\u2013control study in 19 GBS patients from The Netherlands and 22 from Bangladesh. CMAP scans were performed within 2\u2009days of hospital admission and NCS 7\u201314\u2009days after onset of weakness. CMAP scans were also performed in age\u2010 and country\u2010matched controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CMAP scan patterns of patients who were classified as AMAN were distinctly different compared to the CMAP scan patterns of the patients who were classified as AIDP. The most pronounced differences were found in the stimulus intensity parameters.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CMAP scans made at hospital admission demonstrate several characteristics that can be used as an early indicator of GBS subtype.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27172","type":"journal-article","created":{"date-parts":[[2021,1,16]],"date-time":"2021-01-16T07:10:43Z","timestamp":1610781043000},"page":"546-552","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Changes in motor nerve excitability in acute phase Guillain\u2010Barr\u00e9 syndrome"],"prefix":"10.1002","volume":"63","author":[{"given":"Judith","family":"Drenthen","sequence":"first","affiliation":[{"name":"Depts. of Clinical Neurophysiology University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Badrul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Signaling, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, (icddr,b)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhahirul","family":"Islam","sequence":"additional","affiliation":[{"name":"Laboratory of Gut\u2010Brain Signaling, Laboratory Sciences and Services Division, International Centre for Diarrhoeal Disease Research, (icddr,b)  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Quazi D.","family":"Mohammad","sequence":"additional","affiliation":[{"name":"National Institute of Neurosciences and Hospital  Dhaka Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen M.","family":"Maathuis","sequence":"additional","affiliation":[{"name":"Depts. of Clinical Neurophysiology University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerhard H.","family":"Visser","sequence":"additional","affiliation":[{"name":"Stichting Epilepsie Instellingen Nederland (SEIN)  Heemstede The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter A.","family":"van Doorn","sequence":"additional","affiliation":[{"name":"Neurology University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joleen H.","family":"Blok","sequence":"additional","affiliation":[{"name":"Medisch Centrum Eindhoven Veldhoven  Eindhoven The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hubert P.","family":"Endtz","sequence":"additional","affiliation":[{"name":"Medical microbiology and infectious diseases, Erasmus MC University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bart C.","family":"Jacobs","sequence":"additional","affiliation":[{"name":"Neurology University Medical Center Rotterdam  Rotterdam The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00339-1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410440512"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/118.3.597"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410230407"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(06)70603-2"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.07.042"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.59.5.482"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70215-1"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jns5.12003"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20838"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jelekin.2010.11.007"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2010.06.003"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(78)92644-2"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880141111"},{"key":"e_1_2_10_16_1","volume-title":"Manual of Nerve Conduction Studies","author":"Buschbacher RM","year":"2006"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1097\/WNP.0b013e31816a3b28"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2013.07.016"},{"issue":"73","key":"e_1_2_10_19_1","first-page":"17","article-title":"The Landry Guillain\u2010Barre syndrome; 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