{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T09:24:14Z","timestamp":1781169854192,"version":"3.54.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,18]],"date-time":"2021-02-18T00:00:00Z","timestamp":1613606400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In this case\u2010control study, we investigated the association between nucleotide oligomerization domain\u2010like receptor family pyrin domain containing 3 (NLRP3) single\u2010nucleotide polymorphisms (SNPs) rs10754558, rs3806265, rs4612666, and rs35829419 and myasthenia gravis (MG).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Samples from MG patients were selected from a previous study conducted in our neuromuscular clinic, which investigated the association between human leukocyte antigen (HLA) class II genes and MG. Genetic data of controls were also available from another study. The NLRP3 SNPs genotyping was performed using the TaqMan method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 93 blood samples from eligible Iranian patients with MG and 56 samples from healthy controls were obtained. The NLRP3 rs3806265 \u201cC\u201d allele was significantly more frequent in MG patients (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001; odd ratio [OR] = 2.33, 95% confidence interval [CI]: 1.4\u20104.0) than controls. The \u201cCC\u201d genotype of this SNP was found in 18.27% of patients, but none of the controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). The distribution of other SNPs was similar between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>These preliminary results suggest that there might be some associations between the NLRP3 gene polymorphism and MG.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27193","type":"journal-article","created":{"date-parts":[[2021,2,6]],"date-time":"2021-02-06T12:13:19Z","timestamp":1612613599000},"page":"730-736","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Investigating the possible association between <scp>NLRP3<\/scp> gene polymorphisms and myasthenia gravis"],"prefix":"10.1002","volume":"63","author":[{"given":"Elmira","family":"Agah","sequence":"first","affiliation":[{"name":"Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"NeuroImmunology Research Association (NIRA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4763-4310","authenticated-orcid":false,"given":"Shahriar","family":"Nafissi","sequence":"additional","affiliation":[{"name":"Iranian Center for Neurological Research, Department of Neurology, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fatemeh","family":"Saleh","sequence":"additional","affiliation":[{"name":"Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"NeuroImmunology Research Association (NIRA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Payam","family":"Sarraf","sequence":"additional","affiliation":[{"name":"Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abbas","family":"Tafakhori","sequence":"additional","affiliation":[{"name":"Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"},{"name":"NeuroImmunology Research Association (NIRA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seyed Vahid","family":"Mousavi","sequence":"additional","affiliation":[{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"NeuroImmunology Research Association (NIRA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amene","family":"Saghazadeh","sequence":"additional","affiliation":[{"name":"Students' Scientific Research Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Systematic Review and Meta\u2010Analysis Expert Group (SRMEG) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Sadr","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farnaz","family":"Sinaei","sequence":"additional","affiliation":[{"name":"Department of Neurology, Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7219-9923","authenticated-orcid":false,"given":"Bahareh","family":"Mohebbi","sequence":"additional","affiliation":[{"name":"Molecular Immunology Research Center Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahdi","family":"Mahmoudi","sequence":"additional","affiliation":[{"name":"Rheumatology Research Center (RRC), Shariati Hospital Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamideh","family":"Shadi","sequence":"additional","affiliation":[{"name":"Iranian Center of Neurological Research, Neuroscience Institute Tehran University of Medical Sciences  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nima","family":"Rezaei","sequence":"additional","affiliation":[{"name":"Research Center for Immunodeficiencies, Children's Medical Center Tehran University of Medical Sciences  Tehran Iran"},{"name":"Department of Immunology, School of Medicine Tehran University of Medical Sciences  Tehran Iran"},{"name":"Network of Immunity in Infection, Malignancy and Autoimmunity (NIIMA) Universal Scientific Education and Research Network (USERN)  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2013.12.001"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1405.027"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2014.4103"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916934.2015.1030614"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2013.03.010"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2005.06.004"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00009.2014"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2016.57.1.5"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2015.01.008"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2010.11.025"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mib.2012.11.008"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-7643-8550-7_77"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem372"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.13016"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng756"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2018.08.022"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.285"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203316644336"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinre.2017.09.003"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.4238\/2015.October.29.17"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2015.11.021"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/jop.12332"},{"key":"e_1_2_9_24_1","first-page":"2488","volume-title":"Methods for DNA isolation. Part III. Protocols for recombinant DNA isolation, cloning, and sequencing","author":"Roe BA","year":"1995"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/iji.12401"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23604"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/4714836"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2013.08.016"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0004-282X2008000200023"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.4103\/0028-3886.57817"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458510369146"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1177\/1352458514564490"},{"issue":"2","key":"e_1_2_9_33_1","first-page":"175","article-title":"Myasthenia gravis and psoriasis vulgaris","volume":"14","author":"Koc F","year":"2009","journal-title":"Neurosciences"},{"issue":"2","key":"e_1_2_9_34_1","first-page":"153","article-title":"Coexistence of epilepsy, myasthenia gravis and psoriasis vulgaris","volume":"63","author":"Kwan S","year":"2000","journal-title":"Chinese Med J"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2009.07.044"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2013.07.082"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.13657"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-014-0774-9"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10067-017-3900-6"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-015-0288-1"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/3185397"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930903540432"},{"key":"e_1_2_9_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/QAI.0b013e3181dd17d4"},{"key":"e_1_2_9_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-0276140154"},{"key":"e_1_2_9_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22138"},{"key":"e_1_2_9_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3083.2012.02703.x"},{"key":"e_1_2_9_47_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.59.2.287"},{"key":"e_1_2_9_48_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.01-0072com"},{"key":"e_1_2_9_49_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.3.2018"},{"key":"e_1_2_9_50_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-015-0334-4"},{"key":"e_1_2_9_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.05.040"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27193","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27193","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27193","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T16:42:48Z","timestamp":1693327368000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27193"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,18]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1002\/mus.27193"],"URL":"https:\/\/doi.org\/10.1002\/mus.27193","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,18]]},"assertion":[{"value":"2019-08-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}