{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:11:08Z","timestamp":1790809868458,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2021,2,26]],"date-time":"2021-02-26T00:00:00Z","timestamp":1614297600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Spinal muscular atrophy (SMA) most prominently affects proximal limb and bulbar muscles. Despite older case descriptions, ocular motor neuron palsies or other oculomotor abnormalities are not considered part of the phenotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We investigated oculomotor function by testing saccadic eye movements of 15 patients with SMA. Their performance was compared with that of age\u2010matched healthy controls. Horizontal rightward and leftward saccades were recorded by means of video\u2010oculography, whereas subjects looked at light\u2010emitting diode targets placed at \u00b15\u00b0, \u00b110\u00b0, and \u00b115\u00b0 eccentricities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No differences in saccade amplitude gains, peak velocities, peak velocity\u2010to\u2010amplitude ratios, or durations were observed between controls and patients. More specifically, for 5\u00b0 target eccentricities, patients had a mean saccadic peak velocity of 153\u00b0\/s, whereas for 10\u00b0 and 15\u00b0 these values were 268\u00b0\/s and 298\u00b0\/s, respectively. The corresponding mean peak velocities of the control group were 151\u00b0\/s, 264\u00b0\/s, and 291\u00b0\/s.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our results indicate that patients with SMA perform fast and accurate horizontal saccades without evidence of extraocular muscle weakness. These quantitative oculomotor data corroborate clinical experience that neuro\u2010ophthalmic symptoms in SMA are not common and, if present, should prompt suspicion for an alternative neuromuscular disorder.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27204","type":"journal-article","created":{"date-parts":[[2021,2,14]],"date-time":"2021-02-14T11:21:50Z","timestamp":1613301710000},"page":"765-769","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Preserved eye movements in adults with spinal muscular atrophy"],"prefix":"10.1002","volume":"63","author":[{"given":"Evangelos","family":"Anagnostou","sequence":"first","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sophia","family":"Xirou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evangelia","family":"Kararizou","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonidas","family":"Stefanis","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7633-5032","authenticated-orcid":false,"given":"Constantinos","family":"Papadopoulos","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Papadimas","sequence":"additional","affiliation":[{"name":"Department of Neurology, Eginition Hospital University of Athens  Athens Greece"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,26]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14656566.2019.1704732"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24497"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1968.00480040028002"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1969.00480090041005"},{"key":"e_1_2_9_6_1","first-page":"320","article-title":"Congenital total external ophthalmoplegia associated with infantile spinal muscular atrophy. 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