{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T09:14:12Z","timestamp":1787908452650,"version":"build-2784847793"},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,4,5]],"date-time":"2021-04-05T00:00:00Z","timestamp":1617580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Periodic paralysis (PP) is thought to be limited to episodes of muscle weakness, but there are reports of fibromyalgia\u2010like pain in PP. We aimed to evaluate pain and comorbid sleep, fatigue, and mood disorders in PP patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We administered a cross\u2010sectional survey to PP patients at the 2019 Periodic Paralysis Conference. The survey consisted of the Brief Pain Inventory, Widespread Pain Index, Pittsburgh Sleep Quality Index, Modified Fatigue Impact Scale, and ten\u2010question Center for Epidemiologic Studies Depression Scale (CESD\u201010). Descriptive statistics for PP patients were calculated and compared with earlier studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010four individuals with PP took the survey. Of these patients, 52.3% reported a moderate to severe interference of pain on their lives, and 45.5% met the study criteria for fibromyalgia. Patients with <jats:italic>SCN4A<\/jats:italic> mutations had higher rates of fibromyalgia than the next most prevalent gene mutation, <jats:italic>CACNA1S<\/jats:italic>. In patients with pain, there were increased rates of comorbid fatigue, depression, and poor sleep quality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Pain, akin to fibromyalgia, is a significant symptom of PP and can affect quality of life. Pain in PP was more prevalent than in the general population, at a rate comparable with other chronic neuromuscular disease groups. PP patients could benefit from a multidisciplinary approach to assess their pain, sleep, fatigue, and mood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27241","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T02:16:33Z","timestamp":1616552193000},"page":"897-901","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Pain as a significant symptom in patients with periodic paralysis\u2014A cross\u2010sectional survey"],"prefix":"10.1002","volume":"63","author":[{"given":"Alaina","family":"Giacobbe","sequence":"first","affiliation":[{"name":"Department of Neurology University of Pittsburgh Medical Center  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sub","family":"Subramony","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Florida  Gainesville Florida 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