{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,20]],"date-time":"2026-03-20T14:50:32Z","timestamp":1774018232934,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,9]],"date-time":"2021-06-09T00:00:00Z","timestamp":1623196800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Clinical trials addressing treatments for Duchenne muscular dystrophy (DMD) require reliable and valid measurement of muscle contractile function across all disease severity levels. In this work we aimed to evaluate a protocol combining voluntary and evoked contractions to measure strength and excitability of wrist extensor muscles for safety, feasibility, reliability, and discriminant validity between males with DMD and controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Wrist extensor muscle strength and excitability were assessed in males with DMD (N\u00a0=\u00a010; mean \u00b1 standard deviation: 15.4 \u00b1\u20095.9\u2009years of age), using the Brooke Upper Extremity Rating Scale (scored 1\u20106), and age\u2010matched healthy male controls (N\u00a0=\u00a015; 15.5 \u00b1\u20095.0\u2009years of age). Torque and electromyographic (EMG) measurements were analyzed under maximum voluntary and stimulated conditions at two visits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A protocol of multiple maximal voluntary contractions (MVCs) and evoked twitch contractions was feasible and safe, with 96% of the participants completing the protocol and having a less than 7% strength decrement on either measure for both DMD patients and controls (<jats:italic>P<\/jats:italic>\u2009\u2265\u2009.074). Reliability was excellent for voluntary and evoked measurements of torque and EMG (intraclass correlation coefficient [ICC]\u00a0over 0.90 and over 0.85 within and between visits, respectively). Torque, EMG, and timing of twitch\u2010onset measurements discriminated between DMD and controls (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001). Twitch contraction time did not differ significantly between groups (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.10).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Findings from this study show that the protocol is a safe, feasible, reliable, and a valid method to measure strength and excitability of wrist extensors in males with DMD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27323","type":"journal-article","created":{"date-parts":[[2021,5,11]],"date-time":"2021-05-11T18:37:32Z","timestamp":1620758252000},"page":"190-198","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Voluntary and magnetically evoked muscle contraction protocol in males with Duchenne muscular dystrophy: Safety, feasibility, reliability, and validity"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0262-0444","authenticated-orcid":false,"given":"Joyceann 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