{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:35:42Z","timestamp":1790181342401,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,6,12]],"date-time":"2021-06-12T00:00:00Z","timestamp":1623456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Coronavirus disease 2019 (COVID\u201019), a disease caused by severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) infection, has become a global pandemic. Patients with myasthenia gravis (MG), often treated with immunosuppressants, might be at higher risk of developing COVID\u201019 and of demonstrating a severe disease course. We aimed to study prevalence and describe features of COVID\u201019 in MG patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In May 2020, we conducted telephonic interviews with MG patients followed at our referral center. We collected structured data regarding MG and COVID\u201019, which was diagnosed as probable or confirmed according to the European Centre for Disease Prevention and Control case definition. We compared confirmed\u2010COVID\u201019 prevalence calculated from the beginning of the pandemic in MG patients with that of the overall Pavia district.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We interviewed 162 MG patients (median age, 66\u2009y; interquartile range 41\u201077; males 59.9%), 88 from the Pavia district. Three patients had SARS\u2010CoV\u20102\u2010confirmed by polymerase chain reaction and eight had probable\u2010COVID\u201019. In the Pavia district, the prevalence of confirmed\u2010COVID\u201019 among MG patients (1\/88, 1.14%) and overall population (4777\/546\u2009515, 0.87%) did not differ (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.538). Higher Myasthenia Gravis Foundation of America clinicalclass and the need for recent rescue treatment, but not ongoing immunosuppressive treatments, were associated with COVID\u201019 risk. Of 11 MG patients with probable\/confirmed\u2010COVID\u201019, 3 required ventilator support, and 2 elderly patients died of COVID\u201019 respiratory insufficiency. Only 1 of11 patients experienced worsening MG symptoms, which improved after increasing their steroid dose.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The risk of COVID\u201019 in MG patients seems to be no higher than that of the general population, regardless of immunosuppressive therapies. In our cohort, COVID\u201019 barely affected MG course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27324","type":"journal-article","created":{"date-parts":[[2021,5,25]],"date-time":"2021-05-25T04:34:37Z","timestamp":1621917277000},"page":"206-211","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":38,"title":["COVID\u201019 in patients with myasthenia gravis: Epidemiology and disease course"],"prefix":"10.1002","volume":"64","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5990-4640","authenticated-orcid":false,"given":"Pietro","family":"Businaro","sequence":"first","affiliation":[{"name":"Department of Brain and Behavioural Sciences University of Pavia  Pavia Italy"},{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Vaghi","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioural Sciences University of Pavia  Pavia Italy"},{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Marchioni","sequence":"additional","affiliation":[{"name":"Neuroncology Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Diamanti","sequence":"additional","affiliation":[{"name":"Neuroncology Unit IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastiano","family":"Arceri","sequence":"additional","affiliation":[{"name":"Department of Brain and Behavioural Sciences University of Pavia  Pavia Italy"},{"name":"IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Bini","sequence":"additional","affiliation":[{"name":"Neuroncology Unit IRCCS Mondino Foundation  Pavia 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Italy"},{"name":"Unit of Behavioral Neurology IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8749-3706","authenticated-orcid":false,"given":"Sabrina","family":"Ravaglia","sequence":"additional","affiliation":[{"name":"Emergency Neurology IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giulia","family":"Mallucci","sequence":"additional","affiliation":[{"name":"Multiple Sclerosis Research Center IRCCS Mondino Foundation  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Ballante","sequence":"additional","affiliation":[{"name":"BioData Science Center IRCCS Mondino Foundation  Pavia Italy"},{"name":"Department of Mathematics University of Pavia  Pavia Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Franciotta","sequence":"additional","affiliation":[{"name":"IRCCS Ospedale Policlinico San Martino  Genoa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2288-2000","authenticated-orcid":false,"given":"Matteo","family":"Gastaldi","sequence":"additional","affiliation":[{"name":"Neuroncology Unit IRCCS Mondino Foundation  Pavia Italy"},{"name":"Neuroimmunology Research Unit IRCCS Mondino Foundation  Pavia 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Accessed May 15 2020."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2020.102575"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30147-2"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.17023"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.2807\/1560-7917.ES.2020.25.31.2001383"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27324","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27324","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T17:51:59Z","timestamp":1693331519000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6,12]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2021,8]]}},"alternative-id":["10.1002\/mus.27324"],"URL":"https:\/\/doi.org\/10.1002\/mus.27324","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,6,12]]},"assertion":[{"value":"2020-11-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-05-16","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-06-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}