{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T18:54:49Z","timestamp":1793386489304,"version":"4.5.0"},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Neurophysiological patterns in patients with foodborne botulism are rarely described after the acute phase. We report data from a large Italian outbreak of botulism, with patients evaluated at different timepoints after poisoning.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Eighteen male patients (mean age 47\u2009\u00b1\u20098.4\u2009y) underwent 22 clinical and neurophysiological evaluations (4 patients were re\u2010evaluated). The resting compound muscle action potential (CMAP) amplitude, postexercise CMAP amplitude, CMAP change after high\u2010frequency (50\u2009Hz) repetitive nerve stimulation (HFRNS), and motor unit action potentials (MUAPs) were assessed in the acute (4\u20138\u2009days after poisoning; 5 patients), early post\u2010acute (32\u201339\u2009days after poisoning; 5 patients), and late post\u2010acute (66\u201380\u2009days after poisoning; 12 patients) phases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the acute, early post\u2010acute, and late post\u2010acute phases, respectively, reduced CMAP amplitudes were found in 100%, 20%, and 17% of patients; abnormal postexercise CMAP facilitation was observed in 100%, 40%, and 0% of patients; and pathological incremental responses to HFRNS were found in 80%, 50%, and 8% of patients. Baseline CMAP amplitudes, postexercise CMAP facilitation, and CMAP increases in response to HFRNS differed significantly between the acute and post\u2010acute phases. Small MUAPs were found in 100% of patients in the acute and early post\u2010acute phases and in 50% of patients in the late post\u2010acute phase.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The neurophysiological findings of foodborne botulism vary considerably according to the evaluation time point. In the post\u2010acute phase, different neurophysiological techniques must be applied to support a diagnosis of botulism.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27370","type":"journal-article","created":{"date-parts":[[2021,7,13]],"date-time":"2021-07-13T17:06:07Z","timestamp":1626195967000},"page":"435-444","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Neurophysiological patterns of acute and post\u2010acute foodborne botulism"],"prefix":"10.1002","volume":"64","author":[{"given":"Cristina","family":"Boccagni","sequence":"first","affiliation":[{"name":"Unit of Neurophysiology, Rehabilitation Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina","family":"Prestandrea","sequence":"additional","affiliation":[{"name":"Unit of Neurophysiology, Rehabilitation Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"D'Agostino","sequence":"additional","affiliation":[{"name":"Unit of Neurophysiology, Rehabilitation Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Rubino","sequence":"additional","affiliation":[{"name":"Unit of Neurophysiology, Rehabilitation Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Renda","sequence":"additional","affiliation":[{"name":"Medicine Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Sesti","sequence":"additional","affiliation":[{"name":"Emergency Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6289-1887","authenticated-orcid":false,"given":"Sergio","family":"Bagnato","sequence":"additional","affiliation":[{"name":"Unit of Neurophysiology, Rehabilitation Department Giuseppe Giglio Foundation  Cefal\u00f9 Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199806)21:6<701::AID-MUS1>3.0.CO;2-B"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-biochem-013118-111654"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxins12080509"},{"key":"e_1_2_9_5_1","volume-title":"Electromyography and Neuromuscular Disorders","author":"Preston CP","year":"2005"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410010514"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0404.1983.tb04553.x"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199910)22:10<1388::AID-MUS8>3.0.CO;2-3"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21256"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2009.01.019"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-4598(199710)20:10<1284::AID-MUS11>3.0.CO;2-3"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27370","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27370","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27370","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T14:43:52Z","timestamp":1692974632000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27370"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7,29]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2021,10]]}},"alternative-id":["10.1002\/mus.27370"],"URL":"https:\/\/doi.org\/10.1002\/mus.27370","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,7,29]]},"assertion":[{"value":"2021-03-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-07-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}