{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:39Z","timestamp":1786978239602,"version":"build-2736575974"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,10,25]],"date-time":"2021-10-25T00:00:00Z","timestamp":1635120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,1]]},"abstract":"Abstract<\/jats:title>\n \n Introduction\/Aims<\/jats:title>\n Respiratory status is a key determinant of prognosis in patients with Duchenne muscular dystrophy (DMD). We aimed to evaluate the determinants of diaphragm ultrasound and its performance in predicting restrictive respiratory patterns in DMD.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n This was a retrospective study of DMD patients followed in our center and admitted for an annual checkup from 2015 to 2018. We included DMD patients who underwent diaphragm ultrasound and pulmonary functional tests.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n This study included 74 patients with DMD. The right diaphragm thickening fraction (TF) was significantly associated with age (\n P<\/jats:italic>\n \u00a0=\u2009.001), Walton score (\n P<\/jats:italic>\n \u00a0=\u2009.012), inspiratory capacity (IC) (\n P<\/jats:italic>\n \u00a0=\u2009.004), upright forced vital capacity (FVC) (\n P<\/jats:italic>\n \u00a0<\u2009.0001), supine FVC (\n P<\/jats:italic>\n \u00a0=\u2009.038), and maximal inspiratory pressure (MIP) (\n P<\/jats:italic>\n \u00a0=\u2009.002). Right diaphragm excursion was significantly associated with age (\n P<\/jats:italic>\n \u00a0<\u2009.0001), steroid use (\n P<\/jats:italic>\n \u00a0=\u2009.008), history of spinal fusion (\n P<\/jats:italic>\n \u00a0<\u2009.0001), body mass index (BMI) (\n P<\/jats:italic>\n \u00a0=\u2009.002), Walton score (\n P<\/jats:italic>\n \u00a0<\u2009.0001), IC (\n P<\/jats:italic>\n \u00a0<\u2009.0001), upright FVC (\n P<\/jats:italic>\n \u00a0<\u2009.0001), supine FVC (\n P<\/jats:italic>\n \u00a0<\u2009.0001), and MIP (\n P<\/jats:italic>\n \u00a0<\u2009.0001). A right diaphragm TF >28% and a right diaphragm excursion>25.4\u2009mm were associated with an FVC >50% with, respectively, an area under the curve (AUC) of 0.95 (\n P<\/jats:italic>\n \u00a0=\u2009.001) and 0.93 (\n P<\/jats:italic>\n \u00a0<\u2009.001). A left diaphragm TF >26.8% and a left diaphragm excursion >21.5\u2009mm were associated with an FVC >50% with, respectively, an AUC of 0.95 (\n P<\/jats:italic>\n \u00a0=\u2009.011) and 0.97 (\n P<\/jats:italic>\n \u00a0<\u2009.001).\n <\/jats:p>\n <\/jats:sec>\n \n Discussion<\/jats:title>\n Diaphragm excursion and diaphragm TF can predict restrictive pulmonary insufficiency in DMD.<\/jats:p>\n <\/jats:sec>","DOI":"10.1002\/mus.27432","type":"journal-article","created":{"date-parts":[[2021,10,9]],"date-time":"2021-10-09T15:03:10Z","timestamp":1633791790000},"page":"89-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Determinants of diaphragm inspiratory motion, diaphragm thickening, and its performance for predicting respiratory restrictive pattern in\n Duchenne<\/scp>\n muscular dystrophy"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3844-5438","authenticated-orcid":false,"given":"Abdallah","family":"Fayssoil","sequence":"first","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dico\u2010chirurgicale et Pole ventilation \u00e0 domicile CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"},{"name":"APHP, Nord\/Est\/Ile\u2010de\u2010France Neuromuscular reference center, Institut de Myologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"},{"name":"Service de Cardiologie, CHU Ambroise\u2010Par\u00e9, AP\u2010HP Boulogne Billancourt France"},{"name":"Inserm U1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), UVSQ Villejuif France"},{"name":"INSERM U1179, END\u2010ICAP Montigny\u2010le\u2010Bretonneux France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lee S.","family":"Nguyen","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Sorbonne University, INSERM CIC Paris\u2010Est, AP\u2010HP, ICAN, Regional Pharmacovigilance Center, Piti\u00e9\u2010Salp\u00eatri\u00e8re Hospital Paris France"},{"name":"CMC Ambroise Par\u00e9, Research & Innovation (RICAP) Neuilly\u2010sur\u2010Seine France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanya","family":"Stojkovic","sequence":"additional","affiliation":[{"name":"APHP, Nord\/Est\/Ile\u2010de\u2010France Neuromuscular reference center, Institut de Myologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Prigent","sequence":"additional","affiliation":[{"name":"INSERM U1179, END\u2010ICAP Montigny\u2010le\u2010Bretonneux France"},{"name":"Service de Physiologie \u2010 Explorations fonctionnelles, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Carlier","sequence":"additional","affiliation":[{"name":"Service de Radiologie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helge","family":"Amthor","sequence":"additional","affiliation":[{"name":"INSERM U1179, END\u2010ICAP Montigny\u2010le\u2010Bretonneux France"},{"name":"Service de P\u00e9diatrie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Bergounioux","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Zini","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastien","family":"Damez\u2010Fontaine","sequence":"additional","affiliation":[{"name":"Service de P\u00e9diatrie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karim","family":"Wahbi","sequence":"additional","affiliation":[{"name":"APHP, Nord\/Est\/Ile\u2010de\u2010France Neuromuscular reference center, Institut de Myologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"},{"name":"Cardiology Department AP\u2010HP, Cochin Hospital, FILNEMUS, Centre de R\u00e9f\u00e9rence de Pathologie Neuromusculaire Nord\/Est\/Ile de France, Universit\u00e9 Paris Descartes\u2010Sorbonne Paris Cit\u00e9 Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Laforet","sequence":"additional","affiliation":[{"name":"INSERM U1179, END\u2010ICAP Montigny\u2010le\u2010Bretonneux France"},{"name":"Service de Neurologie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Nicolas","sequence":"additional","affiliation":[{"name":"Service de Neurologie, CHU Raymond Poincar\u00e9, APHP, Universit\u00e9 Paris Saclay\/UFR Sciences de la sant\u00e9\u2010Universit\u00e9 de Versailles Saint Quentin en Yvelines Garches France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony","family":"Behin","sequence":"additional","affiliation":[{"name":"APHP, Nord\/Est\/Ile\u2010de\u2010France Neuromuscular reference center, Institut de Myologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Bassez","sequence":"additional","affiliation":[{"name":"APHP, Nord\/Est\/Ile\u2010de\u2010France Neuromuscular reference center, Institut de Myologie, H\u00f4pital Piti\u00e9\u2010Salp\u00eatri\u00e8re Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"France","family":"Leturcq","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology AP\u2010HP, Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rabah","family":"Ben Yaou","sequence":"additional","affiliation":[{"name":"Department of Genetics and Molecular Biology AP\u2010HP, Cochin Hospital Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Mansencal","sequence":"additional","affiliation":[{"name":"Service de Cardiologie, CHU Ambroise\u2010Par\u00e9, AP\u2010HP Boulogne Billancourt France"},{"name":"Inserm U1018, CESP, Team 5 (EpReC, Renal and Cardiovascular Epidemiology), UVSQ Villejuif France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Djillali","family":"Annane","sequence":"additional","affiliation":[{"name":"Service de R\u00e9animation m\u00e9dico\u2010chirurgicale 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Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27432","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27432","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27432","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T12:59:20Z","timestamp":1692968360000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27432"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2022,1]]}},"alternative-id":["10.1002\/mus.27432"],"URL":"https:\/\/doi.org\/10.1002\/mus.27432","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,10,25]]},"assertion":[{"value":"2020-11-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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