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We examined associations between clinical predictors and scoliosis in childhood\u2010onset dystrophinopathy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The progression and treatment of scoliosis were obtained from data collected by the US population\u2010based Muscular Dystrophy Surveillance, Tracking, and Research Network. Associations between loss of independent ambulation (LoA) and corticosteroid use and scoliosis outcomes (ages at or exceeding Cobb angle thresholds [10\u00b0, 20\u00b0, 30\u00b0]; surgery) were estimated using Kaplan\u2013Meier curve estimation and extended Cox regression modeling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed curvature data for 513 of 1054 individuals ascertained. Overall, approximately one\u2010half had at least one radiograph and one\u2010quarter had a curvature of at least 20\u00b0. The average maximum curvature was 25.0\u00b0 (SD\u00a0=\u00a021.5\u00b0) among all individuals and 42.8\u00b0 (SD\u00a0=\u00a018.8\u00b0) among those recommended for surgery. Higher adjusted hazards ratio of curvature (aHR<jats:sub>(curvature)<\/jats:sub> [95% confidence interval]) were found among individuals with LoA compared to those without LoA (aHR<jats:sub>(10)<\/jats:sub>\u00a0=\u00a06.2 [4.4, 8.7], aHR<jats:sub>(20)<\/jats:sub>\u00a0=\u00a015.3 [7.4, 31.7], aHR<jats:sub>(30)<\/jats:sub>\u00a0=\u00a031.6 [7.7, 128.9]), among individuals who did not use corticosteroids compared to those who did (aHR<jats:sub>(10)<\/jats:sub>\u00a0=\u00a01.2 [0.9, 1.7], aHR<jats:sub>(20)<\/jats:sub>\u00a0=\u00a01.8 [1.1, 2.7], aHR<jats:sub>(30)<\/jats:sub>\u00a0=\u00a02.3 [1.3, 4.0]), and among non\u2010ambulatory individuals who used corticosteroids after LoA compared to those who did not (aHR<jats:sub>(10)<\/jats:sub>\u00a0=\u00a01.8 [1.2, 2.8], aHR<jats:sub>(20)<\/jats:sub>\u00a0=\u00a01.6 [1.0, 2.6], aHR<jats:sub>(30)<\/jats:sub>\u00a0=\u00a03.6 [1.6, 7.9]). Scoliosis surgery among individuals with LoA who did not use corticosteroids was more than double compared to those who used (aHR\u00a0=\u00a02.3 [1.3, 4.2]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our retrospective observational study suggests corticosteroids may delay spinal curvature progression and need for scoliosis surgery. Continuing corticosteroids after LoA also showed potential benefits of delaying curvature progression, additional studies are needed to confirm this finding or address the magnitude of benefit.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27464","type":"journal-article","created":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T12:59:51Z","timestamp":1637153991000},"page":"193-202","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["A population\u2010based study of scoliosis among males diagnosed with a dystrophinopathy identified by the Muscular Dystrophy Surveillance, Tracking, and Research Network (<scp>MD STAR<i>net<\/i><\/scp>)"],"prefix":"10.1002","volume":"65","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8633-966X","authenticated-orcid":false,"given":"Kristin M.","family":"Conway","sequence":"first","affiliation":[{"name":"Department of Epidemiology The University of Iowa  Iowa City Iowa 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8452-7189","authenticated-orcid":false,"given":"Russell","family":"Butterfield","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Neurology University of Utah  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Hung","sequence":"additional","affiliation":[{"name":"College of Dental Medicine Roseman University of Health Sciences  South Jordan Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Bounsanga","sequence":"additional","affiliation":[{"name":"Utah Medical Education Council  Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis","family":"Matthews","sequence":"additional","affiliation":[{"name":"Department of Physical Medicine and Rehabilitation University of Colorado and Children's Hospital  Denver Colorado 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