{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T19:42:42Z","timestamp":1789674162346,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,12,21]],"date-time":"2021-12-21T00:00:00Z","timestamp":1640044800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Laryngospasm is an involuntary, sustained closure of sphincter musculature that leads to an unpleasant subjective experience of dyspnea and choking. It is an underreported symptom in amyotrophic lateral sclerosis (ALS). In this study we aimed to better characterize the prevalence and clinical characteristics of laryngospasm in ALS patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The medical records of 571 patients with ALS followed between 2008 and 2018 were searched for evidence of laryngospasm. A total of 23 patients with laryngospasm were identified and the data related to patient and laryngospasm characteristics were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Laryngospasm was reported in 4% of ALS patients. Females comprised 57% of patients and their mean age was 63.4\u2009years. Laryngospasm frequently manifested in patients with moderate bulbar dysfunction and seemed independent of respiratory function. Among laryngospasm patients, 26% were cigarette smokers and 13% had a history of gastroesophageal reflux. The most common reported trigger was excessive saliva irritating the vocal cords (35%) followed by eating a meal (17%). There was significant variation in laryngospasm frequency (up to 5 per hour) and duration (seconds to minutes). Most patients could not identify an effective coping mechanism, although 13% reported that drinking water was effective.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Despite its low prevalence in ALS, laryngospasm should be included in the symptom inquiry. The present findings may improve patient care through increased recognition of the clinical features of laryngospasm in ALS patients, identifying a link between laryngospasm and moderate bulbar dysfunction, and highlighting trigger avoidance as a management strategy. Additional research is required to understand the pathophysiology and optimal treatment.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27466","type":"journal-article","created":{"date-parts":[[2021,11,24]],"date-time":"2021-11-24T06:26:10Z","timestamp":1637735170000},"page":"400-404","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Laryngospasm in amyotrophic lateral sclerosis"],"prefix":"10.1002","volume":"65","author":[{"given":"Ryan D.","family":"Gotesman","sequence":"first","affiliation":[{"name":"Department of Medicine (Neurology) The Ottawa Hospital, and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Lalonde","sequence":"additional","affiliation":[{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas A.","family":"McKim","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, CANVent Respiratory Rehabilitation Services, The Ottawa Hospital Research Institute University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7455-0254","authenticated-orcid":false,"given":"Pierre R.","family":"Bourque","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) The Ottawa Hospital, and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jodi","family":"Warman\u2010Chardon","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) The Ottawa Hospital, and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3687-8571","authenticated-orcid":false,"given":"Jocelyn","family":"Zwicker","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) The Ottawa Hospital, and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari","family":"Breiner","sequence":"additional","affiliation":[{"name":"Department of Medicine (Neurology) The Ottawa Hospital, and Ottawa Hospital Research Institute  Ottawa Ontario Canada"},{"name":"Eric Poulin Centre for Neuromuscular Disease University of Ottawa  Ottawa Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpneuro0853"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1385\/NCC:4:2:163"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000151978.74467.E7"},{"key":"e_1_2_10_5_1","first-page":"1329","article-title":"Vocal cord dysfunction in amyotrophic lateral sclerosis: four cases and a review of the literature","volume":"66","author":"Graaff MM","year":"2009","journal-title":"Arch Neurol."},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1080\/146608200300079536"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(99)00210-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820310017344"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40733-015-0009-z"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2013.09.002"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-198411000-00022"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-7793.2001.t01-1-00237.x"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215107005907"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/gut.30.2.233"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2018.e00779"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.otc.2009.11.004"}],"container-title":["Muscle &amp; 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