{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T08:15:34Z","timestamp":1783412134573,"version":"3.54.6"},"reference-count":22,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,24]],"date-time":"2022-01-24T00:00:00Z","timestamp":1642982400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100005614","name":"Biogen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005614","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Age can affect hand muscles non\u2010uniformly. We investigated the influence of age on the compound muscle action potential (CMAP) amplitude of the hand muscles and the derived split\u2010hand index (SHI).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We studied 244 subjects investigated for suspected myasthenia gravis but without neuromuscular disorders. Abductor pollicis brevis (APB), first dorsal interosseous (FDI), and abductor digiti minimi (ADM) CMAPs were obtained by supramaximal stimulation at the wrist, recording with surface electrodes while checking the best recording site. We applied Tukey's HSD and Kruskal\u2013Wallis one\u2010way analysis of variance for comparing age groups defined by median and interquantile ranges (IQRs). Spearman's rank correlation coefficient and linear regression were used for testing age\u2010dependence of measurements.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Median age was 61.5\u00a0y (first IQR, 44.5; third IQR, 72.0; range 18\u201389). Age and neurophysiological measurements were similar between genders. APB<jats:sub>CMAP<\/jats:sub>, FDI<jats:sub>CMAP<\/jats:sub>, ADM<jats:sub>CMAP<\/jats:sub>, and SHI were correlated with age (<jats:italic>P<\/jats:italic>\u00a0&lt;\u2009.001). Median and cutoff values were significantly different between age groups. APB<jats:sub>CMAP<\/jats:sub>, FDI<jats:sub>CMAP<\/jats:sub>, and ADM<jats:sub>CMAP<\/jats:sub> decreased by 0.8\/0.7\/0.3\u00a0mV\/y, respectively, and SHI decreased 0.15\/y.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The CMAP amplitudes of hand muscles and derived SHI were strongly age\u2010dependent, although this effect was less in ADM. This represents a physiological phenomenon. Future studies using the SHI should consider age effects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27489","type":"journal-article","created":{"date-parts":[[2022,1,7]],"date-time":"2022-01-07T06:55:07Z","timestamp":1641538507000},"page":"463-467","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The senile hand: Age effects on intrinsic hand muscle <scp>CMAP<\/scp> amplitudes influence split\u2010hand index calculations"],"prefix":"10.1002","volume":"65","author":[{"given":"Gon\u00e7alo","family":"Pechirra","sequence":"first","affiliation":[{"name":"Faculdade de Medicina\u2010Instituto de Medicina Molecular Universidade de Lisboa  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8717-8914","authenticated-orcid":false,"given":"Michael","family":"Swash","sequence":"additional","affiliation":[{"name":"Departments of Neurology and Neuroscience Queen Mary University of London  London UK"},{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria Centro Hospitalar Universit\u00e1rio Lisboa\u2010Norte  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7556-0158","authenticated-orcid":false,"given":"Mamede","family":"de Carvalho","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina\u2010Instituto de Medicina Molecular Universidade de Lisboa  Lisbon Portugal"},{"name":"Department of Neurosciences and Mental Health, Hospital de Santa Maria Centro Hospitalar Universit\u00e1rio Lisboa\u2010Norte  Lisbon Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,24]]},"reference":[{"issue":"2","key":"e_1_2_10_2_1","first-page":"S9","article-title":"Dissociated wasting of medial and lateral hand muscles with motor neuron disease","volume":"21","author":"Wilbourn AJ","year":"1994","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20949"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2021-326266"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01477.x"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2012.07.025"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00430-5"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304109"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2019.1606245"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2020.1779299"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.04.163"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2017-317917"},{"key":"e_1_2_10_13_1","unstructured":"Op de Coul AAW.The atrophy of small hand muscles(Thesis). Asten: Schriks drukkerij;1970"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2020-324026"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.65.2.213"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2018.09.024"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2004.05.024"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.43.6.469"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880070812"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/58.2.M146"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2011-301456"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2019-321938"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.03.024"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27489","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27489","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27489","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:39:05Z","timestamp":1692437945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27489"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,24]]},"references-count":22,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,4]]}},"alternative-id":["10.1002\/mus.27489"],"URL":"https:\/\/doi.org\/10.1002\/mus.27489","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,24]]},"assertion":[{"value":"2021-08-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-01-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}