{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T20:35:09Z","timestamp":1791837309626,"version":"4.3.4"},"reference-count":40,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Becker muscular dystrophy (BMD) is an X\u2010linked disease leading to muscle wasting and weakness. The decrease in lean body mass (LBM) in Duchenne muscular dystrophy, has shown correlation with loss of muscle function and bone density (BD). Myokines (including irisin) are hormones secreted by skeletal muscle that allow crosstalk between muscle and bone. The present study analyzed body composition and circulating myokine levels in a cohort of BMD patients; moreover, the association between dual energy X\u2010ray absorptiometry (DXA) parameters, functional motor assessments, and myokine levels was investigated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All patients underwent DXA, blood samples for myokine assays, and functional motor assessments. A group of healthy controls (HCs) was also included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty BMD patients, median age at evaluation 36.0\u00a0y [26.0\u201341.0], were included. Twenty\u2010nine patients underwent whole\u2010body DXA. Median value of total body Z\u2010score was \u22120.70. The prevalence of low skeletal muscle mass defined as appendicular skeletal muscle mass index (ASMMI)\u2009&lt;\u20097.59\u2009kg\/m<jats:sup>2<\/jats:sup> was 83%. Irisin levels were significantly lower in BMD compared to HCs (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03). All DXA parameters showed significant correlation with the functional motor assessments, in particular the h<jats:sup>2<\/jats:sup>\u2010standardized lean mass lower limb index (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.0006); h<jats:sup>2<\/jats:sup>\u2010standardized total fat mass showed negative correlations with North Star Ambulatory Assessment and 6\u00a0min walk test (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.03).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>DXA is a useful tool to evaluate body composition in BMD patients; the decrease in BD and LBM is associated with a reduction of motor function in BMD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27565","type":"journal-article","created":{"date-parts":[[2022,4,27]],"date-time":"2022-04-27T02:12:09Z","timestamp":1651025529000},"page":"63-70","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Body composition and myokines in a cohort of patients with Becker muscular dystrophy"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8015-2597","authenticated-orcid":false,"given":"Andrea","family":"Barp","sequence":"first","affiliation":[{"name":"Neurorehabilitation Unit, NeMO Clinical Center University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Carraro","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, NeMO Clinical Center University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Goggi","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetology Service IRCCS Istituto Ortopedico Galeazzi  Milan Italy"},{"name":"Department of Biotechnology and Translational Medicine University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Lizio","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, NeMO Clinical Center University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alice","family":"Zanolini","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, NeMO Clinical Center University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Messina","sequence":"additional","affiliation":[{"name":"IRCCS Istituto Ortopedico Galeazzi  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Perego","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Biochemistry &amp; Molecular Biology IRCCS Istituto Ortopedico Galeazzi  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Verdelli","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Endocrinology IRCCS Istituto Ortopedico Galeazzi  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Lombardi","sequence":"additional","affiliation":[{"name":"Laboratory of Experimental Biochemistry &amp; Molecular Biology IRCCS Istituto Ortopedico Galeazzi  Milan Italy"},{"name":"Department of Athletics, Strength and Conditioning Pozna\u0144 University of Physical Education  Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria Ada","family":"Sansone","sequence":"additional","affiliation":[{"name":"Neurorehabilitation Unit, NeMO Clinical Center University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Corbetta","sequence":"additional","affiliation":[{"name":"Endocrinology and Diabetology Service IRCCS Istituto Ortopedico Galeazzi  Milan Italy"},{"name":"Department of Biomedical, Surgery and Dental Sciences University of Milan  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.39.8.1011"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmr.2012.08.005"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/01241398-200001000-00016"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097\u20104598(199606)19:6<777::AID\u2010MUS15>3.0.CO;2\u2010I"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880170411"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiology.216.2.r00jl46559"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21212"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.585644"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/ijo.2014.42"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2015.08.001"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010014\u20102673\u2010x"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12672"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100218"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/ggi.13030"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00320"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010010\u20101307\u20101"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0164385"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357\u2010013\u20109556\u20105"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1532\u20105415.2002.50216.x"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532\u20105415.2007.01436.x"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009520"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamda.2013.02.010"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21808"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.06.368"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pri.520"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/0471722146"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"issue":"1","key":"e_1_2_11_29_1","first-page":"77","article-title":"Bone mineral density and bone metabolism in patients with Duchenne muscular dystrophy. 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