{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T12:04:22Z","timestamp":1788264262749,"version":"build-2803163510"},"reference-count":165,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T00:00:00Z","timestamp":1660521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    The Notch signaling pathway is a key regulator of skeletal muscle development and regeneration. Over the past decade, the discoveries of three new muscle disease genes have added a new dimension to the relationship between the Notch signaling pathway and skeletal muscle:\n                    <jats:italic>MEGF10<\/jats:italic>\n                    ,\n                    <jats:italic>POGLUT1<\/jats:italic>\n                    , and\n                    <jats:italic>JAG2<\/jats:italic>\n                    . We review the clinical syndromes associated with pathogenic variants in each of these genes, known molecular and cellular functions of their protein products with a particular focus on the Notch signaling pathway, and potential novel therapeutic targets that may emerge from further investigations of these diseases. The phenotypes associated with two of these genes,\n                    <jats:italic>POGLUT1<\/jats:italic>\n                    and\n                    <jats:italic>JAG2<\/jats:italic>\n                    , clearly fall within the realm of muscular dystrophy, whereas the third,\n                    <jats:italic>MEGF10<\/jats:italic>\n                    , is associated with a congenital myopathy\/muscular dystrophy overlap syndrome classically known as early\u2010onset myopathy, areflexia, respiratory distress, and dysphagia. JAG2 is a canonical Notch ligand, POGLUT1 glycosylates the extracellular domain of Notch receptors, and MEGF10 interacts with the intracellular domain of NOTCH1. Additional genes and their encoded proteins relevant to muscle function and disease with links to the Notch signaling pathway include\n                    <jats:italic>TRIM32<\/jats:italic>\n                    ,\n                    <jats:italic>ATP2A1<\/jats:italic>\n                    (SERCA1),\n                    <jats:italic>JAG1<\/jats:italic>\n                    ,\n                    <jats:italic>PAX7<\/jats:italic>\n                    , and\n                    <jats:italic>NOTCH2NLC<\/jats:italic>\n                    . There is enormous potential to identify convergent mechanisms of skeletal muscle disease and new therapeutic targets through further investigations of the Notch signaling pathway in the context of skeletal muscle development, maintenance, and disease.\n                  <\/jats:p>","DOI":"10.1002\/mus.27684","type":"journal-article","created":{"date-parts":[[2022,8,15]],"date-time":"2022-08-15T06:31:19Z","timestamp":1660545079000},"page":"530-544","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":50,"title":["The Notch signaling pathway in skeletal muscle health and disease"],"prefix":"10.1002","volume":"66","author":[{"given":"Dorianmarie","family":"Vargas\u2010Franco","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raghav","family":"Kalra","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurology University of Florida College of Medicine  Gainesville Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Draper","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Research Institute Tufts Medical Center  Boston Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7430-124X","authenticated-orcid":false,"given":"Christina A.","family":"Pacak","sequence":"additional","affiliation":[{"name":"Paul and Sheila Wellstone Muscular Dystrophy Center University of Minnesota Medical School  Minneapolis Minnesota"},{"name":"Department of Neurology University of Minnesota Medical School  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8078-1027","authenticated-orcid":false,"given":"Atsushi","family":"Asakura","sequence":"additional","affiliation":[{"name":"Paul and Sheila Wellstone Muscular Dystrophy Center University of Minnesota Medical School  Minneapolis Minnesota"},{"name":"Department of Neurology University of Minnesota Medical School  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4270-7325","authenticated-orcid":false,"given":"Peter B.","family":"Kang","sequence":"additional","affiliation":[{"name":"Paul and Sheila Wellstone Muscular Dystrophy Center University of Minnesota Medical School  Minneapolis Minnesota"},{"name":"Department of Neurology University of Minnesota Medical School  Minneapolis Minnesota"},{"name":"Institute for Translational Neuroscience University of Minnesota Medical School  Minneapolis Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,15]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/323646a0"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13395\u2010020\u201000240\u20107"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.80.7.1977"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/1472\u20106793\u201011\u20106"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.151787"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3655"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.123.6.1857"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25730"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2014.07.011"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03940"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.12.100"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1086\/505332"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.779"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.547"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/383707a0"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1009729"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2019.07.002"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/74307"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255\u2010022\u201000533\u20109"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2015.07.015"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.10.049"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797\u2010235"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI128152"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/10.2.163"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2021.03.020"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1260419"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u20104614\u20100899\u20104_2"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.37880"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.087916"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.02950"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0070\u20102153(10)92003\u20106"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymeth.2014.03.029"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/19083"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2006.01.035"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.22.21.7688\u20107700.2002"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.17.3241"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1997.8564"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.124.8.1485"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.1457"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.06753\u201011"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.17355"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010017\u201000522\u20107"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.08.019"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.26508\/lsa.201900437"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2018.09.007"},{"key":"e_1_2_7_47_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00890\u201014"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184396"},{"key":"e_1_2_7_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00426\u201016"},{"key":"e_1_2_7_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.21232"},{"key":"e_1_2_7_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2006.11.002"},{"key":"e_1_2_7_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.995"},{"key":"e_1_2_7_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10048\u2010012\u20100315\u2010z"},{"key":"e_1_2_7_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.01.013"},{"key":"e_1_2_7_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz064"},{"key":"e_1_2_7_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25054"},{"key":"e_1_2_7_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2016.06.005"},{"key":"e_1_2_7_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2022.01.009"},{"key":"e_1_2_7_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.09.017"},{"key":"e_1_2_7_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12872"},{"key":"e_1_2_7_61_1","doi-asserted-by":"publisher","DOI":"10.1093\/dnares\/8.2.85"},{"key":"e_1_2_7_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.06.015"},{"key":"e_1_2_7_63_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200709083"},{"key":"e_1_2_7_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2007.03.041"},{"key":"e_1_2_7_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3066"},{"key":"e_1_2_7_66_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873\u20103468.13348"},{"key":"e_1_2_7_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2014.06.018"},{"key":"e_1_2_7_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10877"},{"key":"e_1_2_7_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx189"},{"key":"e_1_2_7_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/2211\u20105463.13031"},{"key":"e_1_2_7_71_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.2010.05432.x"},{"key":"e_1_2_7_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddtec.2013.02.004"},{"key":"e_1_2_7_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896\u20106273(03)00289\u20107"},{"key":"e_1_2_7_74_1","doi-asserted-by":"publisher","DOI":"10.1093\/genetics\/152.2.567"},{"key":"e_1_2_7_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2446"},{"key":"e_1_2_7_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.05.029"},{"key":"e_1_2_7_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06901"},{"key":"e_1_2_7_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.30"},{"key":"e_1_2_7_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2006.04.028"},{"key":"e_1_2_7_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0000120"},{"key":"e_1_2_7_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3850\u201015.2016"},{"key":"e_1_2_7_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12776"},{"key":"e_1_2_7_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2010.08.050"},{"key":"e_1_2_7_84_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471\u2010213X\u201014\u20102"},{"key":"e_1_2_7_85_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.773"},{"key":"e_1_2_7_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2012.07.014"},{"key":"e_1_2_7_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2004.07.034"},{"key":"e_1_2_7_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2014.07.061"},{"key":"e_1_2_7_89_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.6350\u201011.2012"},{"key":"e_1_2_7_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2013.08.002"},{"key":"e_1_2_7_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2013.12.003"},{"key":"e_1_2_7_92_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201505815"},{"key":"e_1_2_7_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scr.2017.08.020"},{"key":"e_1_2_7_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401\u2010019\u201002117\u20106"},{"key":"e_1_2_7_95_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010020\u20100840\u20103"},{"key":"e_1_2_7_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2018.05.007"},{"key":"e_1_2_7_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2005.08.027"},{"key":"e_1_2_7_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419\u2010020\u201003314\u2010y"},{"key":"e_1_2_7_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.12.016"},{"key":"e_1_2_7_100_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.060020"},{"key":"e_1_2_7_101_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M117.800102"},{"key":"e_1_2_7_102_1","doi-asserted-by":"publisher","DOI":"10.1089\/dna.2017.4052"},{"key":"e_1_2_7_103_1","doi-asserted-by":"publisher","DOI":"10.3233\/JND\u2010190457"},{"key":"e_1_2_7_104_1","doi-asserted-by":"publisher","DOI":"10.1051\/medsci\/2021191"},{"key":"e_1_2_7_105_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2000.3469"},{"key":"e_1_2_7_106_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.20.18.6913\u20106922.2000"},{"key":"e_1_2_7_107_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.4.12a.2188"},{"key":"e_1_2_7_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.1996.0310"},{"key":"e_1_2_7_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104773(97)00146\u20109"},{"key":"e_1_2_7_110_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.17.10.6057"},{"key":"e_1_2_7_111_1","doi-asserted-by":"publisher","DOI":"10.1006\/geno.1999.6045"},{"key":"e_1_2_7_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014\u20105793(88)80690\u20102"},{"key":"e_1_2_7_113_1","first-page":"2430","article-title":"High expression of Notch ligand Jagged2 is associated with the metastasis and recurrence in urothelial carcinoma of bladder","volume":"6","author":"Li W","year":"2013","journal-title":"Int J Clin Exp Pathol"},{"key":"e_1_2_7_114_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535\u20107163.MCT\u201014\u20100501"},{"key":"e_1_2_7_115_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18391"},{"key":"e_1_2_7_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12092600"},{"key":"e_1_2_7_117_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182640"},{"key":"e_1_2_7_118_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201018\u20101617"},{"key":"e_1_2_7_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010020\u20101026\u20100"},{"key":"e_1_2_7_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002\u20109440(10)65325\u20104"},{"key":"e_1_2_7_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10843"},{"key":"e_1_2_7_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104773(02)00043\u20106"},{"key":"e_1_2_7_123_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540405200409"},{"key":"e_1_2_7_124_1","doi-asserted-by":"publisher","DOI":"10.1177\/002215540305100712"},{"key":"e_1_2_7_125_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102004\u201011\u20104237"},{"key":"e_1_2_7_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2006.09.008"},{"key":"e_1_2_7_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104773(01)00523\u20108"},{"key":"e_1_2_7_128_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013\u20101288"},{"key":"e_1_2_7_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20366"},{"key":"e_1_2_7_130_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0607062104"},{"key":"e_1_2_7_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10059\u2010010\u20100101\u20104"},{"key":"e_1_2_7_132_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.3.950"},{"key":"e_1_2_7_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0925\u20104773(01)00469\u20105"},{"key":"e_1_2_7_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbaexp.2006.10.001"},{"key":"e_1_2_7_135_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1617467114"},{"key":"e_1_2_7_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2015.05.020"},{"key":"e_1_2_7_137_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000363"},{"key":"e_1_2_7_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2009.02.023"},{"key":"e_1_2_7_139_1","doi-asserted-by":"publisher","DOI":"10.1534\/genetics.107.080994"},{"key":"e_1_2_7_140_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00740\u201013"},{"key":"e_1_2_7_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201021663\u2010w"},{"key":"e_1_2_7_142_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhaa064"},{"key":"e_1_2_7_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.01.015"},{"key":"e_1_2_7_144_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045\u2010020\u201001015\u20109"},{"key":"e_1_2_7_145_1","doi-asserted-by":"publisher","DOI":"10.1086\/339083"},{"key":"e_1_2_7_146_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddp167"},{"key":"e_1_2_7_147_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201110067"},{"key":"e_1_2_7_148_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.E20\u201007\u20100453"},{"key":"e_1_2_7_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2012.03.012"},{"key":"e_1_2_7_150_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz410"},{"key":"e_1_2_7_151_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1096\u2010191"},{"key":"e_1_2_7_152_1","doi-asserted-by":"publisher","DOI":"10.1002\/mgg3.552"},{"key":"e_1_2_7_153_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0797\u2010243"},{"key":"e_1_2_7_154_1","doi-asserted-by":"publisher","DOI":"10.1093\/gerona\/62.1.9"},{"key":"e_1_2_7_155_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.015917"},{"key":"e_1_2_7_156_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0005205"},{"key":"e_1_2_7_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41436\u2010019\u20100532\u2010z"},{"key":"e_1_2_7_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.06.001"},{"key":"e_1_2_7_159_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.084756"},{"key":"e_1_2_7_160_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478\u2010020\u201001084\u20104"},{"key":"e_1_2_7_161_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100459\u2010y"},{"key":"e_1_2_7_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588\u2010019\u20100458\u2010z"},{"key":"e_1_2_7_163_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz372"},{"key":"e_1_2_7_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114169"},{"key":"e_1_2_7_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2101592118"},{"key":"e_1_2_7_166_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10071649"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27684","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27684","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27684","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T02:53:13Z","timestamp":1692499993000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27684"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8,15]]},"references-count":165,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/mus.27684"],"URL":"https:\/\/doi.org\/10.1002\/mus.27684","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,8,15]]},"assertion":[{"value":"2022-01-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-24","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-15","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}