{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:50:36Z","timestamp":1786978236894,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction\/Aim<\/jats:title>\n                    <jats:p>The most common limb girdle muscular dystrophy (LGMD) worldwide is LGMD type R1 (LGMDR1). The aim of this study was to correlate the MRI findings with functional scores and to describe the whole\u2010body MRI (WBMRI) pattern in a LGMDR1 Brazilian cohort.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>LGMDR1 patients under follow\u2010up in three centers were referred for the study. Clinical data were collected and a functional evaluation was performed, consisting of Gardner\u2010Medwin and Walton (GMW) and Brooke scales. All patients underwent a WBMRI study (1.5T) with axial T1 and STIR images. Fifty\u2010one muscles were semiquantitatively assessed regarding fatty infiltration and muscle edema.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The study group consisted of 18 patients. The highest fatty infiltration scores involved the serratus anterior, biceps femoris long head, adductor magnus, and lumbar erector spinae. There was a latero\u2010medial and caudo\u2010cranial descending gradient of involvement of the paravertebral muscles, with erector spinae being significantly more affected than the transversospinalis muscles (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). A striped appearance that has been dubbed the \u201cpseudocollagen sign\u201d was present in 72% of the patients. There was a positive correlation between the MRI score and GMW (Rho:0.83) and Brooke (Rho:0.53) scores.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Discussion<\/jats:title>\n                    <jats:p>WBMRI in LGMDR1 allows a global patient evaluation including involvement of the paraspinal muscles, usually an underestimated feature in the clinical and imaging study of myopathies. Knowledge of the WBMRI pattern of LGMDR1 involvement can be useful in the diagnostic approach and in future studies to identify the best target muscles to serve as outcome measures in clinical trials.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/mus.27686","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T08:46:42Z","timestamp":1658911602000},"page":"471-478","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Whole\u2010Body MRI in Limb Girdle Muscular Dystrophy Type\n                    <scp>R1<\/scp>\n                    \/\n                    <scp>2A<\/scp>\n                    : Correlation With Clinical Scores"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4439-9143","authenticated-orcid":false,"given":"La\u00eds U.","family":"Aivazoglou","sequence":"first","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"},{"name":"Division of Musculoskeletal Imaging Laborat\u00f3rio Delboni Auriemo \/ DASA (Diagn\u00f3sticos da Am\u00e9rica SA)  Barueri SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julio B.","family":"Guimar\u00e3es","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alice F.","family":"Costa","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"},{"name":"Division of Musculoskeletal Imaging Laborat\u00f3rio Delboni Auriemo \/ DASA (Diagn\u00f3sticos da Am\u00e9rica SA)  Barueri SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 Yui","family":"Aihara","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"},{"name":"Division of Musculoskeletal Imaging Laborat\u00f3rio Delboni Auriemo \/ DASA (Diagn\u00f3sticos da Am\u00e9rica SA)  Barueri SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiano N.","family":"Cardoso","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wladimir B. V. De R.","family":"Pinto","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Diseases, Department of Neurology and Neurosurgery Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7416-7108","authenticated-orcid":false,"given":"Paulo Victor S.","family":"de Souza","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Diseases, Department of Neurology and Neurosurgery Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9 M. S.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edmar","family":"Zanoteli","sequence":"additional","affiliation":[{"name":"Departamento de Neurologia, Faculdade de Medicina Universidade de S\u00e3o Paulo  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Acary S. B.","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Division of Neuromuscular Diseases, Department of Neurology and Neurosurgery Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5485-7937","authenticated-orcid":false,"given":"Alzira A. S.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Doen\u00e7as Neuromusculares da Faculdade de Medicina do ABC Departamento de Neuroci\u00eancias  Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Artur Da R. C.","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Department of Radiology and Diagnostic Imaging Universidade Federal de S\u00e3o Paulo (UNIFESP)  S\u00e3o Paulo SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.13597"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010019\u201009539\u2010y"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26169"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2004.10.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010021\u201007931\u20109"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0100292"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010016\u20108350\u20106"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11547\u2010010\u20100531\u20102"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00415\u2010005\u20100684\u20104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv332"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/0366\u20106999.186638"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.39.4.475"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.wnl.0000324927.28817.9b"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/ker262"},{"key":"e_1_2_12_16_1","unstructured":"TeamRC.R: a language and environment for statistical computing. 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