{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,31]],"date-time":"2025-08-31T10:26:05Z","timestamp":1756635965956,"version":"3.40.5"},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,9,2]],"date-time":"2022-09-02T00:00:00Z","timestamp":1662076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Fasciculations are an early clinical hallmark of amyotrophic lateral sclerosis (ALS), amenable to detection by high\u2010density surface electromyography (HDSEMG). In conjunction with the Surface Potential Quantification Engine (SPiQE), HDSEMG offers improved spatial resolution for the analysis of fasciculations. This study aims to establish an optimal recording duration to enable longitudinal remote monitoring in the home.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty patients with ALS and five patients with benign fasciculation syndrome (BFS) underwent serial 30\u2009min HDSEMG recordings from biceps brachii and gastrocnemii. SPiQE was independently applied to abbreviated epochs within each 30\u2010min recording (0\u20135, 0\u201310, 0\u201315, 0\u201320, and 0\u201325\u2009min), outputting fasciculation frequency, amplitude median and amplitude interquartile range. Bland\u2013Altman plots and intraclass correlation coefficients (ICC) were used to assess agreement with the validated 30\u2010min recording.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 506 full recordings were included. The 5\u00a0min recordings demonstrated diverse and relatively poor agreement with the 30\u2009min baselines across all parameters, muscles and patient groups (ICC\u00a0=\u00a00.32\u20130.86). The 15\u2010min recordings provided more acceptable and stable agreement (ICC\u00a0=\u00a00.78\u20130.98), which did not substantially improve in longer recordings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>For the detection and quantification of fasciculations in patients with ALS and BFS, HDSEMG recordings can be halved from 30 to 15\u2009min without significantly compromising the primary outputs. Reliance on a shorter recording duration should lead to improved tolerability and repeatability among patients, facilitating longitudinal remote monitoring in patients' homes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27701","type":"journal-article","created":{"date-parts":[[2022,8,18]],"date-time":"2022-08-18T11:48:35Z","timestamp":1660823315000},"page":"625-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A shortened surface electromyography recording is sufficient to facilitate home fasciculation assessment"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3031-3502","authenticated-orcid":false,"given":"Mark","family":"Crook\u2010Rumsey","sequence":"first","affiliation":[{"name":"UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abdi Malik","family":"Musa","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raquel","family":"Iniesta","sequence":"additional","affiliation":[{"name":"Biostatistics and Health Informatics Department, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emmanuel","family":"Drakakis","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martyn G.","family":"Boutelle","sequence":"additional","affiliation":[{"name":"Department of Bioengineering Imperial College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher E.","family":"Shaw","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5972-0748","authenticated-orcid":false,"given":"James","family":"Bashford","sequence":"additional","affiliation":[{"name":"UK Dementia Research Institute, Department of Basic and Clinical Neuroscience, Maurice Wohl Clinical Neuroscience Institute, Institute of Psychiatry, Psychology and Neuroscience King's College London  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,2]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/14660820050515539"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awq290"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2012-304545"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2016.02.011"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.880151104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbiomech.2010.01.027"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.03.032"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2019.09.015"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa018"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa141"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27139"},{"key":"e_1_2_10_13_1","unstructured":"Team R. 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R: \u201cA language and environment for statistical computing.\u201d (2021)."},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(86)90837-8"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-0003-9-78"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3182a823e0"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27701","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27701","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27701","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T06:52:38Z","timestamp":1692514358000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27701"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,2]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1002\/mus.27701"],"URL":"https:\/\/doi.org\/10.1002\/mus.27701","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"type":"print","value":"0148-639X"},{"type":"electronic","value":"1097-4598"}],"subject":[],"published":{"date-parts":[[2022,9,2]]},"assertion":[{"value":"2022-02-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-07","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}