{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T06:34:48Z","timestamp":1769150088231,"version":"3.49.0"},"reference-count":38,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,8,27]],"date-time":"2022-08-27T00:00:00Z","timestamp":1661558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Data on safety and tolerability of the vaccines against severe acute respiratory virus coronavirus\u20102 (SARS\u2010CoV\u20102, or coronavirus disease\u20102019 [COVID\u201019]) in patients with myasthenia gravis (MG) are currently limited. In this study we investigated the safety of mRNA\u2010based two\u2010dose vaccination in a cohort of patients with MG.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This investigation was a prospective observational study of messenger RNA (mRNA)\u2010based vaccines administered to patients with MG with stable disease. Local and systemic reactogenicity after injection was monitored for each dose administered. The patients were categorized and clinically assessed following the recommendations of the Myasthenia Gravis Foundation of America.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010six males and 55 females (mean age at first vaccine dose, 58.8\u2009years; standard deviation,\u00a0=\u200917.1\u2009years) received vaccines. Seventy\u2010two patients (79.1%) were taking one or more immunosuppressant(s). The most frequent adverse effects were injection\u2010site pain, fatigue, myalgia, chills, fever, and headache. Local and systemic reactions were transient; 58.2% of the patients developed one or more reaction(s). There were no anaphylactic reactions. None of the patients had a myasthenic crisis, and two developed a mild deterioration compared with their Quantitative Myasthenia Gravis baseline score. The clinical outcome scores showed no exacerbation of MG symptoms. Patients over 65\u2009years of age developed fewer adverse effects. COVID\u201019 vaccination did not induce clinical exacerbation in stable patients with MG, regardless of their age, sex, history of myasthenic crisis, or whether they were taking immunosuppressants.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our data are consistent with the mRNA COVID\u201019 vaccine being well tolerated in patients with well\u2010controlled MG. The findings may contribute to decisions in vaccination campaigns in the future.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27703","type":"journal-article","created":{"date-parts":[[2022,8,11]],"date-time":"2022-08-11T13:03:40Z","timestamp":1660223020000},"page":"612-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Safety of <scp>mRNA COVID<\/scp>\u201019 vaccines in patients with well\u2010controlled myasthenia gravis"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3127-7486","authenticated-orcid":false,"given":"Josep","family":"Gamez","sequence":"first","affiliation":[{"name":"Neurology Department, GMA Clinic, European Reference Network on Rare Neuromuscular Diseases Autonomous University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alejandro","family":"Gamez","sequence":"additional","affiliation":[{"name":"Neurophtalmology Department Hospital San Rafael  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesc","family":"Carmona","sequence":"additional","affiliation":[{"name":"Department of Genetics, Microbiology and Statistics University of Barcelona  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,27]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.01053"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2020.117230"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30413-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.26065"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2021.1042"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27130"},{"key":"e_1_2_9_8_1","unstructured":"ReddelS KiersL BuzzardK et al.COVID\u201019 vaccination discussion\u2013\u2010immune mediated neuromuscular diseases.https:\/\/myastheniaalliance.org.au\/wp-content\/uploads\/2021\/03\/covid-19-vaccination-discussion-ni-v7-distribution.pdf. Accessed May 31 2022"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2021.117362"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000011669"},{"key":"e_1_2_9_11_1","unstructured":"Myasthenia Gravis Foundation of America.COVID\u201019 resource center.https:\/\/myasthenia.org\/mg-community\/covid-19-resource-center. Accessed November 22 2021."},{"key":"e_1_2_9_12_1","unstructured":"US Centers for Disease Control and Prevention.Possible side effects after getting a COVID\u201019 vaccine.https:\/\/www.cdc.gov\/coronavirus\/2019-ncov\/vaccines\/expect\/after.html#:~:text=possible%20side%20effects%20after%20getting%20a%20covid-19%20vaccine. 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