{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,15]],"date-time":"2026-08-15T01:08:53Z","timestamp":1786756133250,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,10,7]],"date-time":"2022-10-07T00:00:00Z","timestamp":1665100800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007155","name":"Medical Research Council Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007155","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012819","name":"Egyptian Cultural and Educational Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012819","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/aims<\/jats:title><jats:p>Inclusion body myositis (IBM) is a myopathic condition but in some patients has been associated with an axonal length\u2010dependent polyneuropathy. In this study, we quantified the cross\u2010sectional area of the sciatic and tibial nerves in patients with IBM comparing with Charcot\u2013Marie\u2013Tooth disease type 1A (CMT1A) and healthy controls using magnetic resonance neurography (MRN).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>MRN of the sciatic and tibial nerves was performed at 3T using MPRAGE and Dixon acquisitions. Nerve cross\u2010sectional area (CSA) was measured at the mid\u2010thigh and upper third calf regions by an observer blinded to the diagnosis. Correlations were performed between these measurements and clinical data.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 20 patients with IBM, 20 CMT1A and 29 healthy controls (age\u2010 and sex\u2010matched) were studied. Sciatic nerve CSA was significantly enlarged in patients with IBM and CMT1A compared to controls (sciatic nerve mean CSA 62.3\u00a0\u00b1\u200922.9\u2009mm<jats:sup>2<\/jats:sup> (IBM) vs. 35.5\u00a0\u00b1\u20099.9\u2009mm<jats:sup>2<\/jats:sup> (controls), <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001; and 96.9\u00a0\u00b1\u200935.5\u2009mm<jats:sup>2<\/jats:sup> (CMT1A) vs. 35.5\u00a0\u00b1\u20099.9\u2009mm<jats:sup>2<\/jats:sup> (controls); <jats:italic>p<\/jats:italic>\u00a0&lt;\u20090.001). Tibial nerve CSA was also enlarged in IBM and CMT1 patients compared to controls.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>MRN reveals significant hypertrophy of the sciatic and tibial nerves in patients with IBM and CMT1A compared to controls. Further studies are needed to correlate with neurophysiological measures and assess whether this finding is useful diagnostically.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27728","type":"journal-article","created":{"date-parts":[[2022,9,24]],"date-time":"2022-09-24T05:33:57Z","timestamp":1663997637000},"page":"744-749","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evidence of nerve hypertrophy in patients with inclusion body myositis on lower limb MRI"],"prefix":"10.1002","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9812-6418","authenticated-orcid":false,"given":"Mostafa","family":"Elmansy","sequence":"first","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"},{"name":"Department of Radiology Mansoura University Hospitals  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasper M.","family":"Morrow","sequence":"additional","affiliation":[{"name":"Queen Square Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sachit","family":"Shah","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arne","family":"Fischmann","sequence":"additional","affiliation":[{"name":"Institute of Radiology and Nuclear Medicine and Breast Center St. Anna Hirslanden Klinik St. Anna  Lucerne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Wastling","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary M.","family":"Reilly","sequence":"additional","affiliation":[{"name":"Queen Square Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael G.","family":"Hanna","sequence":"additional","affiliation":[{"name":"Queen Square Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eman Mohamed","family":"Helmy","sequence":"additional","affiliation":[{"name":"Department of Radiology Mansoura University Hospitals  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh Saleh","family":"El\u2010Essawy","sequence":"additional","affiliation":[{"name":"Department of Radiology Mansoura University Hospitals  Mansoura Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S.","family":"Thornton","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"},{"name":"Queen Square Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tarek A.","family":"Yousry","sequence":"additional","affiliation":[{"name":"Neuroradiological Academic Unit UCL Queen Square Institute of Neurology  London UK"},{"name":"Queen Square Centre for Neuromuscular Diseases, Department of Neuromuscular Diseases UCL Queen Square Institute of Neurology  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2009.11.003"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2013.08.007"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.2010.211334"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14303"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/112.3.727"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-6111-8_43"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clinph.2020.07.025"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-012-0321-4"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(15)00242-2"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2006.01.015"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20958"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2011.00350.x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000002864"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24661"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-017-5087-2"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21009"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-510X(00)00395-6"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27728","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27728","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27728","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T15:54:24Z","timestamp":1692633264000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27728"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10,7]]},"references-count":17,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,12]]}},"alternative-id":["10.1002\/mus.27728"],"URL":"https:\/\/doi.org\/10.1002\/mus.27728","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,10,7]]},"assertion":[{"value":"2022-04-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-10-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}