{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T01:44:49Z","timestamp":1790646289473,"version":"4.1.0"},"reference-count":23,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,10,31]],"date-time":"2022-10-31T00:00:00Z","timestamp":1667174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Transthyretin amyloidosis (ATTR) proteins can infiltrate skeletal muscle and infrequently cause a myopathy. <jats:sup>99m<\/jats:sup>Technetium\u2010pyrophosphate (<jats:sup>99m<\/jats:sup>Tc\u2010PYP) is a validated biomarker for cardiac involvement in variant and wild\u2010type ATTR (ATTRv and ATTRwt, respectively). The aim of this study was to test the hypothesis that <jats:sup>99m<\/jats:sup>Tc\u2010PYP is a biomarker for muscle burden of ATTR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Radioisotope uptake in the deltoid muscles of patients with ATTR was compared to uptake in control subjects without amyloidosis in a retrospective study. <jats:sup>99m<\/jats:sup>Tc\u2010PYP scans were evaluated in 11 patients with ATTR (7 ATTRv, 4 ATTRwt) and 14 control subjects. Mean count (MC) values were measured in circular regions of interest (ROIs) 2.5\u20133.8\u00a0cm<jats:sup>2<\/jats:sup> in area. Tracer uptake was quantified in the heart, contralateral chest (CC), and deltoid muscles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Tracer uptake was significantly higher over the deltoids and heart but not the CC, in patients with ATTR than in control subjects. MC values were 120.1\u00a0\u00b1\u200943.7 (mean\u2009\u00b1\u2009SD) in ATTR patients and 78.9\u00a0\u00b1\u200920.4 in control subjects over the heart (<jats:italic>p<\/jats:italic>\u00a0=\u20090.005), 73.3\u00b1\u200921.0 and 63.5\u00a0\u00b1\u200914.4 over CC (<jats:italic>p<\/jats:italic>\u00a0=\u20090.09), and 37.0\u00a0\u00b1\u200911.7 and 26.0\u00a0\u00b1\u20097.1 averaged over both deltoid muscles (<jats:italic>p<\/jats:italic>\u00a0=\u20090.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p><jats:sup>99m<\/jats:sup>Tc\u2010PYP is a potential biomarker for ATTR amyloid burden in skeletal muscle.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27740","type":"journal-article","created":{"date-parts":[[2022,10,12]],"date-time":"2022-10-12T14:53:45Z","timestamp":1665586425000},"page":"111-116","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["<sup>99m<\/sup>Technetium\u2010pyrophosphate bone scan: A potential biomarker for the burden of transthyretin amyloidosis in skeletal muscle: A preliminary study"],"prefix":"10.1002","volume":"67","author":[{"given":"Richard","family":"Wlodarski","sequence":"first","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaitlin","family":"Seibert","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoum P.","family":"Issa","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bill","family":"O'Brien\u2010Penney","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Betty","family":"Soliven","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nitasha","family":"Sarswat","sequence":"additional","affiliation":[{"name":"Department of Medicine, Section of Cardiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Appelbaum","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3986-5709","authenticated-orcid":false,"given":"Kourosh","family":"Rezania","sequence":"additional","affiliation":[{"name":"Department of Neurology University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,10,31]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-308724"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2011.03.004"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2018.07.092"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.3109\/03009734.2014.895786"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26723"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716153"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1716793"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1805689"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.14285"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(20)30368-9"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.116.021612"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardfail.2021.06.012"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamacardio.2016.2839"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ehjci\/jeu107"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2015.02.001"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12350-013-9803-2"},{"key":"e_1_2_11_18_1","unstructured":"American 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