{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T10:50:24Z","timestamp":1776682224066,"version":"3.51.2"},"reference-count":18,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,19]],"date-time":"2022-12-19T00:00:00Z","timestamp":1671408000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Due to muscular weakness and cardiopulmonary dysfunction, patients with muscular dystrophy (MD) have an increased risk of serious complications from coronavirus disease\u20102019 (COVID\u201019). Although vaccination is recommended, COVID\u201019 vaccination safety and immunogenicity in these patients are unknown. We investigated reaction frequency, post\u2010vaccine antibody titers after two mRNA COVID\u201019 vaccine doses, and clinical predictors of antibody response among patients with MD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited 171 inpatients with MD receiving two BNT162b2 mRNA COVID\u201019 vaccine doses from seven hospitals. Blood samples were obtained from 53 inpatients before the first dose and 28 to 30\u2009days after the second dose, and antibody titers were measured.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 104 (60.8%) and 115 (67.6%) patients had side effects after the first and second doses, respectively. These were generally mild and self\u2010limited. Multiple logistic regression analysis showed that a bedridden state was associated with reduced side effects (odds ratio [OR] =\u20090.29; 95% confidence interval [CI], 0.12 to 0.71). The antibody titers of all participants changed from negative to positive after two vaccine doses. The geometric mean titer (GMT) of the inpatients was 239 (95% CI, 159.3 to 358.7). Older age (relative risk [RR]\u00a0=\u00a00.97; 95% CI, 0.95 to 0.99) and bedridden state (RR\u00a0=\u00a00.27; 95% CI, 0.14 to 0.51) were associated with a lower antibody titer. Patients with myotonic dystrophy type 1 (DM1) had a lower GMT than patients with other MDs (RR\u00a0=\u00a00.42; 95% CI, 0.21 to 0.85).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>COVID\u201019 vaccination is safe and immunogenic in inpatients with MD. Patients with DM1 appear to have a poorer COVID\u201019 antibody response than those with other MDs.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27761","type":"journal-article","created":{"date-parts":[[2022,12,7]],"date-time":"2022-12-07T17:18:28Z","timestamp":1670433508000},"page":"117-123","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Safety and immunogenicity of <scp>mRNA COVID<\/scp>\u201019 vaccine in inpatients with muscular dystrophy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-4007","authenticated-orcid":false,"given":"Tomoko","family":"Saito","sequence":"first","affiliation":[{"name":"Department of Neurology National Hospital Organization, Osaka Toneyama Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Saito","sequence":"additional","affiliation":[{"name":"Division of Child Neurology, Department of Neurology National Hospital Organization, Toneyama Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1865-4953","authenticated-orcid":false,"given":"Hiroya","family":"Hashimoto","sequence":"additional","affiliation":[{"name":"Core Laboratory, Nagoya City University Graduate School of Medical Sciences Clinical Research Management Center, Nagoya City University Hospital  Nagoya Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katsuhisa","family":"Ogata","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Higashisaitama National Hospital  Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michio","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Akita National Hospital  Akita Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroto","family":"Takada","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Aomori National Hospital  Aomori Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Kuru","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Suzuka National Hospital  Suzuka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Kimura","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Asahikawa Medical Center  Asahikawa Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Akinori","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Clinical Research National Hospital Organization, Matsumoto Medical Center  Nagano Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tsuyoshi","family":"Matsumura","sequence":"additional","affiliation":[{"name":"Department of Neurology National Hospital Organization, Osaka Toneyama Medical Center  Osaka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,19]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"World Muscle Society.Covid\u201019 and people with neuromuscular disorders: World Muscle Society position and advice.https:\/\/www.worldmusclesociety.org\/file\/ec4c36f3-8ce1-4762-981\u2009e-a9b81823fd8a\/WMS%20covid-19%20advice%2028-03-2020%201800.pdf. Accessed October 1 2021."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19010406"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2021.11.006"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2034577"},{"key":"e_1_2_11_6_1","unstructured":"Ministry of Health Labour and Welfare. Health status survey after the first inoculation of the new corona vaccine.https:\/\/www.mhlw.go.jp\/stf\/seisakunitsuite\/bunya\/vaccine_kenkoujoukyoutyousa.html. Accessed October 1 2021."},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resinv.2021.06.003"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.05.087"},{"key":"e_1_2_11_9_1","unstructured":"National Cancer Institute.Adverse events\/CTCAE.https:\/\/ctep.cancer.gov\/protocoldevelopment\/adverse_effects.htm. Updated April 30 2021. Accessed May 26 2021."},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600\u20100404.1986.tb04639.x"},{"key":"e_1_2_11_11_1","first-page":"29","article-title":"Immunological studies in myotonic dystrophy","volume":"19","author":"Walker GL","year":"1983","journal-title":"Clin Exp Neurol"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13760\u2010020\u201001514\u2010z"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10072\u2010019\u201003763\u20100"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.1186"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2021.07.042"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943\u2010021\u201001311\u2010z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41541\u2010021\u201000369\u20106"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.17743"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amsu.2021.102956"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27761","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27761","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27761","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T09:48:45Z","timestamp":1692438525000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27761"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,19]]},"references-count":18,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/mus.27761"],"URL":"https:\/\/doi.org\/10.1002\/mus.27761","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,12,19]]},"assertion":[{"value":"2022-04-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-19","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}