{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T09:28:53Z","timestamp":1751880533498,"version":"3.40.5"},"reference-count":43,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,12,26]],"date-time":"2022-12-26T00:00:00Z","timestamp":1672012800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF14OC0011633","NNF18OC0052301"],"award-info":[{"award-number":["NNF14OC0011633","NNF18OC0052301"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018732","name":"Vissing Fonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018732","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Autonomic dysfunction is a common complication of small\u2010fiber neuropathy (SFN). In this study we aimed to assess the applicability of autonomic microvascular indices as a potential marker for SFN assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fifteen patients with confirmed SFN (idiopathic neuropathy [n\u00a0=\u00a010], chemotherapy\u2010induced peripheral neuropathy [n\u00a0=\u00a02], impaired glucose tolerance [n\u00a0=\u00a01], hereditary transthyretin amyloidosis (hATTR) [n\u00a0=\u00a01], pulmonary sarcoidosis [n\u00a0=\u00a01]) and 15 matched control subjects underwent assessment of vascular skin responses assessed through laser Doppler flowmetry and evaluation of microvascular vessel and nerve density in skin biopsies. All participants underwent peripheral autonomic evaluation by quantitative sudomotor axon reflex testing (QSART).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We found no significant differences in vascular skin responses, or in any microvascular skin biopsy markers, when comparing SFN with control subjects. We found no correlation between vascular skin responses and skin biopsy indices. We saw no significant difference in any microvascular indices when comparing subjects with and without impaired sudomotor function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest markers of peripheral microvascular innervation and function are not associated with the diagnosis of SFN. Furthermore, we saw no association between microvascular markers and sudomotor function, suggesting that these are independent and unrelated components of the autonomic nervous system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27770","type":"journal-article","created":{"date-parts":[[2022,12,12]],"date-time":"2022-12-12T05:00:12Z","timestamp":1670821212000},"page":"146-153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Functional and structural markers of peripheral microvascular autonomic neuropathy"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9819-8793","authenticated-orcid":false,"given":"Thorsten K.","family":"Rasmussen","sequence":"first","affiliation":[{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P\u00e1ll","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Core Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nanna B.","family":"Finnerup","sequence":"additional","affiliation":[{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Troels S.","family":"Jensen","sequence":"additional","affiliation":[{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens R.","family":"Nyengaard","sequence":"additional","affiliation":[{"name":"Core Center for Molecular Morphology, Section for Stereology and Microscopy, Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Pathology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Astrid J.","family":"Terkelsen","sequence":"additional","affiliation":[{"name":"Danish Pain Research Center, Department of Clinical Medicine Aarhus University Aarhus Denmark"},{"name":"Department of Neurology Aarhus University Hospital Aarhus Denmark"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,12,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.wco.0000177330.35147.70"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30329-0"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/14737175.2020.1794825"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2013.06.006"},{"issue":"342","key":"e_1_2_12_6_1","article-title":"Which method for diagnosing small fiber neuropathy?","volume":"11","author":"Fabry V","year":"2020","journal-title":"Front Neurol"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)74815-7"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.000"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181a2e8b8"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181f39cf4"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1042\/cs0700577"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2741\/S105"},{"key":"e_1_2_12_13_1","first-page":"583","article-title":"Evaluation of skin vasomotor reflexes by using laser doppler velocimetry","volume":"58","author":"Low PA","year":"1983","journal-title":"Mayo Clin Proc"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology10040333"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26889"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1529-8027.2008.00180.x"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2006.01.041"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2010.07.026"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2010.03023.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mayocp.2012.10.013"},{"key":"e_1_2_12_21_1","doi-asserted-by":"crossref","first-page":"P1. 282","DOI":"10.1212\/WNL.84.14_supplement.P1.282","article-title":"Normative values for sudomotor axon reflex testing using QSWEAT\u2122 (P1.282)","volume":"84","author":"Sletten D","year":"2015","journal-title":"Neurology"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmpb.2013.07.024"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11916-011-0181-7"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.23891"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.20551"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864211004318"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318230b0f4"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.21626"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz015"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001488"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179573518771703"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.06.017"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-1652"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1532-2149.2013.00379.x"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0227709"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.1988.tb08353.x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/jappl.1976.41.6.826"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(96)03136-3"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02886695"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2005.04.004"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)62249-6"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.22126"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12332"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vph.2017.01.004"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mus.27770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,10]],"date-time":"2024-10-10T05:44:33Z","timestamp":1728539073000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12,26]]},"references-count":43,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,2]]}},"alternative-id":["10.1002\/mus.27770"],"URL":"https:\/\/doi.org\/10.1002\/mus.27770","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"type":"print","value":"0148-639X"},{"type":"electronic","value":"1097-4598"}],"subject":[],"published":{"date-parts":[[2022,12,26]]},"assertion":[{"value":"2022-03-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-06","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}