{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T19:19:32Z","timestamp":1770837572235,"version":"3.50.1"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,3,3]],"date-time":"2023-03-03T00:00:00Z","timestamp":1677801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>There is limited knowledge regarding the impact of severe acute respiratory syndrome coronavirus 2 (SARS\u2010CoV\u20102) vaccines \u03bfn coronavirus disease 2019 (COVID\u201019) disease course in people with myasthenia gravis. In this study, we aimed to investigate whether SARS\u2010CoV\u20102 vaccination influences hospitalization and mortality due to COVID\u201019 in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a retrospective analysis of administrative data extracted from the Greek nationwide database that holds the COVID\u201019 disease and vaccination registry, as well as all medical prescription records. The study period extended from the onset of the pandemic (February 2020) until the 10th of January 2022.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 278 people with myasthenia gravis (mean age 58.1\u00a0\u00b1\u200917.2, 47.5% males) who tested positive for SARS\u2010CoV\u20102. Of those, 139 (50%) were not vaccinated at the time of infection. Multivariable binary logistic regression analysis showed that the probability of hospitalization increased with age (odds ratio [OR]: 1.058; 95% confidence interval [CI], 1.036\u20131.080; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and immunosuppressive treatment (OR: 2.872; 95% CI 1.412\u20135.839; <jats:italic>p<\/jats:italic>\u00a0=\u2009.004), and decreased with vaccination (OR: 0.244; 95% CI 0.132\u20130.453; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001). The probability of a fatal outcome increased with age (OR: 1.085; 95% CI 1.043\u20131.129; <jats:italic>p<\/jats:italic>\u00a0&lt;\u2009.001) and decreased with vaccination (OR: 0.315; 95% CI 0.125\u20130.791; <jats:italic>p<\/jats:italic>\u00a0=\u2009.014).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>SARS\u2010CoV\u20102 vaccination significantly reduces hospitalization and mortality due to COVID\u201019 in people with myasthenia gravis. This study regarding the efficacy of these vaccines, together with previous studies regarding their safety, provide evidence to support their use in people with myasthenia gravis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27805","type":"journal-article","created":{"date-parts":[[2023,2,23]],"date-time":"2023-02-23T05:03:50Z","timestamp":1677128630000},"page":"412-416","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["The impact of <scp>SARS\u2010CoV<\/scp>\u20102 immunization on <scp>COVID<\/scp>\u201019 disease course in people with myasthenia gravis"],"prefix":"10.1002","volume":"67","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4737-3707","authenticated-orcid":false,"given":"Christos","family":"Bakirtzis","sequence":"first","affiliation":[{"name":"Second Department of Neurology Aristotle University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marina\u2010Kleopatra","family":"Boziki","sequence":"additional","affiliation":[{"name":"Second Department of Neurology Aristotle University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5026-0842","authenticated-orcid":false,"given":"Maria\u2010Valeria","family":"Karakasi","sequence":"additional","affiliation":[{"name":"Third Department of Psychiatry Aristotle University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theodoros","family":"Moysiadis","sequence":"additional","affiliation":[{"name":"Department of Computer Science, School of Sciences and Engineering University of Nicosia  Nicosia Cyprus"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Grigoriadis","sequence":"additional","affiliation":[{"name":"Second Department of Neurology Aristotle University of Thessaloniki, School of Medicine  Thessaloniki Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000009566"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000024971"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/vaccines9101112"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2021.19499"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2118946"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gaceta.2021.10.085"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010020\u201019741\u20106"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.15581"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/21501327211051933"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27179"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.733418"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2022.01.013"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.15348"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2022.120225"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200002"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vaccine.2021.10.068"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.20411\/pai.v6i1.435"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16851"},{"key":"e_1_2_11_20_1","unstructured":"COVID\u201019 latest evidence risk factors and risk groups European Centre for Disease Prevention and Control. Websitehttps:\/\/www.ecdc.europa.eu\/en\/covid-19\/latest-evidence\/risk-factors-risk-groups Updated January 21 2022. Accessed November 27 2022"},{"key":"e_1_2_11_21_1","unstructured":"COVID\u201019 Vaccines for People Who Are Moderately or Severely Immunocompromised.Centers for Disease Control and Prevention Web site https:\/\/www.cdc.gov\/coronavirus\/2019ncov\/vaccines\/recommendations\/immuno.html Updated November 3 2022. 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