{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T16:42:07Z","timestamp":1793292127144,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T00:00:00Z","timestamp":1682640000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["23\u20105"],"award-info":[{"award-number":["23\u20105"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009438","name":"National Center of Neurology and Psychiatry","doi-asserted-by":"publisher","award":["23\u20104"],"award-info":[{"award-number":["23\u20104"]}],"id":[{"id":"10.13039\/501100009438","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>In idiopathic inflammatory myopathies (IIMs), the change in muscle echogenicity and its histopathological basis are not well understood. We quantitatively measured muscle echogenicity in patients with IIMs and evaluated its correlation with disease activity and histopathological findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study involved patients with IIMs who underwent both ultrasonography (US) and muscle biopsy, as well as age\u2010 and sex\u2010matched rheumatoid arthritis patients as inflammatory disease controls. On US, axial images of the right biceps brachii and vastus medialis were obtained. Standardized histopathological scoring was used to quantitatively measure each pathological domain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Forty\u2010two patients (17 with inclusion body myositis [IBM] and 25 with IIMs other than IBM) and 25 controls were included. The muscle echo intensity (EI) of patients with IIMs was significantly higher than that of controls. Muscle EI showed significant correlations with creatine kinase (r\u2009=\u20090.66, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) and muscle strength (r\u2009=\u2009\u22120.73, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) in patients with non\u2010IBM IIMs. In patients with IBM, moderate correlation was found between muscle EI and quadriceps muscle strength (r\u2009=\u2009\u22120.53, <jats:italic>p<\/jats:italic>\u2009=\u2009.028). Histopathologically, the number of infiltrating CD3+ inflammatory cells correlated with muscle EI in the non\u2010IBM group (r\u2009=\u20090.56, <jats:italic>p<\/jats:italic>\u2009=\u2009.017), but not in the IBM group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Muscle EI may be useful as a surrogate marker of muscle inflammation in non\u2010IBM IIM. Increased muscle EI may be difficult to interpret in patients with long\u2010standing IBM, which has advanced and complex histopathology.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27833","type":"journal-article","created":{"date-parts":[[2023,4,29]],"date-time":"2023-04-29T06:59:43Z","timestamp":1682751583000},"page":"39-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Correlation of muscle ultrasound with clinical and pathological findings in idiopathic inflammatory myopathies"],"prefix":"10.1002","volume":"68","author":[{"given":"Takeshi","family":"Yoshida","sequence":"first","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"},{"name":"Department of Rheumatology Chikamori Hospital  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroki","family":"Yamazaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukako","family":"Nishimori","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research, National Institute of Neuroscience National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"},{"name":"Department of Clinical Genome Analysis Medical Genome Center (MGC), NCNP  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoko","family":"Takamatsu","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Fukushima","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusuke","family":"Osaki","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshinori","family":"Taniguchi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Metabolism, Nephrology and Rheumatology Kochi Medical School Hospital  Nankoku Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taiki","family":"Nozaki","sequence":"additional","affiliation":[{"name":"Department of Radiology St. Luke's International Hospital  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Kumon","sequence":"additional","affiliation":[{"name":"Department of Rheumatology Chikamori Hospital  Kochi Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8030-9504","authenticated-orcid":false,"given":"Jemima","family":"Albayda","sequence":"additional","affiliation":[{"name":"School of Medicine, Division of Rheumatology Johns Hopkins University  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9452-112X","authenticated-orcid":false,"given":"Ichizo","family":"Nishino","sequence":"additional","affiliation":[{"name":"Department of Neuromuscular Research, National Institute of Neuroscience National Center of Neurology and Psychiatry (NCNP)  Tokyo Japan"},{"name":"Department of Clinical Genome Analysis Medical Genome Center (MGC), NCNP  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuishin","family":"Izumi","sequence":"additional","affiliation":[{"name":"Department of Neurology Tokushima University School of Medicine  Tokushima 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