{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:00:34Z","timestamp":1781305234904,"version":"3.54.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T00:00:00Z","timestamp":1683936000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Cytosolic 5\u2032\u2010nucleotidase 1A (cN\u20101A) autoantibodies have been recognized as myositis\u2010related autoantibodies. However, their correlations with clinical characteristics and other myositis\u2010specific and myositis\u2010associated autoantibodies (MSAs\/MAAs) are still unclear. We aimed to establish the prevalence and clinical and laboratory associations of cN\u20101A autoantibodies in a cohort of patients with connective tissue diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 567 participants (182 idiopathic inflammatory myopathies [IIM], 164 systemic lupus erythematosus [SLE], 121 systemic sclerosis [SSc], and 100 blood donors [BD]) were tested for the presence of cN\u20101A autoantibodies and other myositis\u2010specific and myositis\u2010associated autoantibodies (MSAs\/MAAs). Clinical and laboratory characteristics were compared between anti\u2010cN\u20101A positive and negative patients with sporadic inclusion body myositis (sIBM) and between anti\u2010cN\u20101A positive and negative patients with non\u2010IBM IIM.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In the sIBM cohort, 30 patients (46.9%) were anti\u2010cN\u20101A positive vs. 18 (15.2%) in the non\u2010IBM IIM cohort, 17 (10%) were anti\u2010cN\u20101A positive in the SLE cohort and none in the SSc or the BD cohorts. Anti\u2010cN\u20101A positivity had an overall sensitivity of 46.9% and a specificity of 93.2% for sIBM. Dysphagia was more frequent in the anti\u2010cN\u20101A positive vs. negative sIBM patients (<jats:italic>p<\/jats:italic>\u2009=\u2009.04). In the non\u2010IBM IIM group, being anti\u2010cN\u20101A antibody positive was associated with the diagnosis polymyositis (<jats:italic>p<\/jats:italic>\u2009=\u2009.04) and overlap\u2010myositis (<jats:italic>p<\/jats:italic>\u2009=\u2009.04) and less disease damage evaluated by physician global damage score (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>cN\u20101A autoantibodies were predominantly found in IIM patients and was associated with dysphagia in sIBM patients. Notably, anti\u2010cN\u20101A appears to identify a distinct phenotype of anti\u2010cN\u20101A positive non\u2010IBM IIM patients with a milder disease course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27841","type":"journal-article","created":{"date-parts":[[2023,5,13]],"date-time":"2023-05-13T07:44:37Z","timestamp":1683963877000},"page":"73-80","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Myositis\u2010related autoantibody profile and clinical characteristics stratified by anti\u2010cytosolic 5\u2032\u2010nucleotidase <scp>1A<\/scp> status in connective tissue diseases"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2581-8912","authenticated-orcid":false,"given":"Louise Pyndt","family":"Diederichsen","sequence":"first","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"},{"name":"Department of Rheumatology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Line Vinderslev","family":"Iversen","sequence":"additional","affiliation":[{"name":"Department of Dermatology Copenhagen University Hospital, Bispebjerg Hospital  Copenhagen Denmark"},{"name":"Department of Dermatology Odense University Hospital  Odense Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoffer Tandrup","family":"Nielsen","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f8ren","family":"Jacobsen","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie\u2010Louise","family":"Hermansen","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0664-0709","authenticated-orcid":false,"given":"Nanna","family":"Witting","sequence":"additional","affiliation":[{"name":"Department of Neurology Copenhagen University Hospital, Rigshospitalet  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rikke","family":"Cortes","sequence":"additional","affiliation":[{"name":"Department of Congenital Disorders Statens Serum Institut  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sine S\u00f8ndergaard","family":"Korsholm","sequence":"additional","affiliation":[{"name":"Center for Rheumatology and Spine Diseases 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