{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T18:30:13Z","timestamp":1785522613578,"version":"3.56.0"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Non\u2010invasive ventilation (NIV) is routinely prescribed to support the respiratory system in Duchenne muscular dystrophy (DMD) patients; however, factors improving NIV usage are unclear. We aimed to identify predictors of NIV adherence in DMD patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a multicenter retrospective analysis of DMD patients prescribed NIV and followed at (1) The Hospital for Sick Children, Canada; (2) Rady Children's Hospital San Diego, USA; and (3) University of California San Diego Health, USA, between February 2016 and October 2020. The primary and secondary outcomes were 90\u2010day period NIV adherence and clinical and socioeconomic predictors of NIV adherence.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 59 DMD patients prescribed NIV (mean\u2009\u00b1\u2009SD age\u2009=\u200920.1\u2009\u00b1\u20096.7\u2009y). Overall, percentage of nights used, and average nightly usage, were 79.9\u2009\u00b1\u200931.1% and 7.23\u2009\u00b1\u20094.12\u2009h, respectively. Compared with children, adults had higher percentage of nights used (92.9\u2009\u00b1\u200916.9% vs. 70.4\u2009\u00b1\u200936.9%; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and average nightly usage (9.5\u2009\u00b1\u20094.7\u2009h vs. 5.3\u2009\u00b1\u20093.7\u2009h; <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Non\u2010English language (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), and absence of deflazacort prescription (<jats:italic>P<\/jats:italic>\u2009=\u2009.02) were significantly associated with higher percentage of nights used while Hispanic ethnicity (<jats:italic>P<\/jats:italic>\u2009=\u2009.01), low household income (<jats:italic>P<\/jats:italic>\u2009=\u2009.02), and absence of deflazacort prescription (<jats:italic>P<\/jats:italic>\u2009=\u2009.02) were significantly associated with higher nightly usage. Based on univariable analysis, older age and declining forced vital capacity were associated with increased percentage of nights used and increased average nightly usage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Certain clinical and socioeconomic determinants had a significant impact on NIV adherence in DMD patients, providing insight into those at risk for high versus low compliance with respiratory therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27848","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T09:45:04Z","timestamp":1685007904000},"page":"48-56","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Non\u2010invasive ventilation usage and adherence in children and adults with Duchenne muscular dystrophy: A multicenter analysis"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2353-5687","authenticated-orcid":false,"given":"Manju","family":"Hurvitz","sequence":"first","affiliation":[{"name":"Division of Respiratory Medicine, Department of Pediatrics University of California San Diego, Rady Children's Hospital  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2725-4636","authenticated-orcid":false,"given":"Kanokkarn","family":"Sunkonkit","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, The Hospital for Sick Children University of Toronto  Toronto Ontario Canada"},{"name":"Division of Pulmonary and Critical Care Medicine, Department of Pediatrics, Faculty of Medicine Chiang Mai University  Chiang Mai Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Defante","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Pediatrics University of California San Diego, Rady Children's Hospital  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Lesser","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Pediatrics University of California San Diego, Rady Children's Hospital  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Skalsky","sequence":"additional","affiliation":[{"name":"Division of Rehabilitation Medicine, Department of Orthopedics, Rady Children's Hospital San Diego University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeremy","family":"Orr","sequence":"additional","affiliation":[{"name":"Division of Pulmonary and Critical Care Medicine, Department of Medicine University of California San Diego  San Diego California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abhishek","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Columbia University  New York City New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3032-5434","authenticated-orcid":false,"given":"Reshma","family":"Amin","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, The Hospital for Sick Children University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4882-5629","authenticated-orcid":false,"given":"Rakesh","family":"Bhattacharjee","sequence":"additional","affiliation":[{"name":"Division of Respiratory Medicine, Department of Pediatrics University of California San Diego, Rady Children's Hospital  San Diego California 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