{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,26]],"date-time":"2026-03-26T14:55:44Z","timestamp":1774536944013,"version":"3.50.1"},"reference-count":8,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Previous studies have reported weak correlations between neurophysiological measurements and subjective severity of symptoms in carpal tunnel syndrome, with Pearson <jats:italic>r<\/jats:italic>\u2009\u2264\u20090.26. We hypothesize that this resulted in part from patient\u2010to\u2010patient variability in the assessment of subjective severity using tools such as the Boston Carpal Tunnel Questionnaire. To compensate for this, we aimed to assess within\u2010patient differences in symptom and test result severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In our study we used retrospective data from 13 005 patients with bilateral electrophysiological results and 790 patients with bilateral ultrasound imaging drawn from the Canterbury CTS database. Measures of neurophysiological (nerve conduction studies [NCS] grade) and anatomical (cross\u2010sectional area on ultrasound) severity within individual patients were compared between the right and left hands, eliminating individual variation in the way in which patients interpret the questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There was a correlation found between right\u2010hand NCS grade and symptom severity score (Pearson <jats:italic>r<\/jats:italic> = \u22120.302, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, n\u2009=\u200913,005), but not between right\u2010hand cross\u2010sectional area and symptom severity (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.058, <jats:italic>P<\/jats:italic>\u2009=\u2009.10, n\u2009=\u2009790). In the within\u2010subject analyses, there were significant correlations between symptoms and NCS grade (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.6, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, n\u2009=\u20096521) and between symptoms and cross\u2010sectional area (Pearson <jats:italic>r<\/jats:italic>\u2009=\u20090.3. <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, n\u2009=\u2009433).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>The simple correlation between symptomatic and electrophysiological severity was comparable with previous studies, but within\u2010patient analysis revealed that the relationship was stronger than previously reported and strong enough to be clinically useful. The relationship between symptoms and cross\u2010sectional area measurement on ultrasound imaging was weaker.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27924","type":"journal-article","created":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T13:13:47Z","timestamp":1688217227000},"page":"264-268","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Do nerve conduction studies or ultrasound imaging correlate more closely with subjective symptom severity in carpal tunnel syndrome?"],"prefix":"10.1002","volume":"68","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2660-2192","authenticated-orcid":false,"given":"Sarah N.","family":"Fargaly","sequence":"first","affiliation":[{"name":"Faculty of Medicine Helwan University  Cairo Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5591-6022","authenticated-orcid":false,"given":"Jeremy D. P.","family":"Bland","sequence":"additional","affiliation":[{"name":"East Kent Hospitals University Foundation NHS Trust  Canterbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1054\/jhsb.2000.0361","article-title":"Relationship between the self\u2010administered Boston Questionnaire and electrophysiological findings in follow\u2010up of surgically\u2010treated carpal tunnel syndrome","volume":"25","author":"Mondelli M","year":"2000","journal-title":"J Hand Surg."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apmr.2006.10.013"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pmrj.2009.08.117"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.2106\/00004623-199311000-00002"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-4598(200008)23:8<1280::AID-MUS20>3.0.CO;2-Y"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cnp.2018.02.005"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27173"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26618"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27924","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,4]],"date-time":"2024-01-04T05:27:40Z","timestamp":1704346060000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27924"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":8,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1002\/mus.27924"],"URL":"https:\/\/doi.org\/10.1002\/mus.27924","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"2022-11-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-14","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}