{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,23]],"date-time":"2025-09-23T14:02:07Z","timestamp":1758636127101},"reference-count":34,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T00:00:00Z","timestamp":1695945600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["800\u201020200179"],"award-info":[{"award-number":["800\u201020200179"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Effective strategies for rapid recovery after surgery are needed. Therefore, we investigated the effects of exercise prehabilitation (EP) and hindlimb unloading (HU) on muscle loss and contractility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty\u2010two Sprague\u2013Dawley rats (12\u2009wk old) were divided into normal control (NCON, <jats:italic>n<\/jats:italic>\u2009=\u20095), hindlimb unloading control (HCON, <jats:italic>n<\/jats:italic>\u2009=\u200910), and exercise prehabilitation followed by hindlimb unloading (Ex\u2010preH, <jats:italic>n<\/jats:italic>\u2009=\u20097) groups. Ex\u2010PreH performed exercise training for 14\u2009days before hindlimb unloading for 14\u2009days. Body composition was evaluated, along with muscle strength and function. The soleus (SOL) and extensor digitorum longus (EDL) muscle contractile properties were analyzed at the whole\u2010muscle level. The titin concentration and myosin heavy chain (MHC) type composition were analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>There were no effects of Ex\u2010preH on total mass, lean mass, or muscle weight. Physical function was significantly higher in the Ex\u2010preH group than in the HCON group (39.5\u00b0 vs. 35.7\u00b0). The SOL twitch force (19.6 vs. 7.1\u2009mN\/m<jats:sup>2<\/jats:sup>) and specific force (107.3 vs. 61.2\u2009mN\/m<jats:sup>2<\/jats:sup>) were greater in Ex\u2010preH group than in HCON group. EDL shortening velocity was higher in Ex\u2010preH group than in HCON group (13.2 vs. 5.0\u2009FL\/s). The SOL full\u2010length titin level was higher in Ex\u2010preH group than in HCON group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Exercise prehabilitation did not prevent muscle mass loss followed by muscle wasting, although it minimized the reduction of physical function. Therefore, exercise prehabilitation should be considered for rapid functional recovery after disuse due to surgery and injuries.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27979","type":"journal-article","created":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T11:44:00Z","timestamp":1695987840000},"page":"886-893","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of exercise prehabilitation on muscle atrophy and contractile properties in hindlimb\u2010unloaded rats"],"prefix":"10.1002","volume":"68","author":[{"given":"Hyo\u2010Seong","family":"Yeo","sequence":"first","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Seoul National University Institute on Aging  Seoul South Korea"},{"name":"Aging &amp; Mobility Biophysics Laboratory, Seoul National University Bundang Hospital  Seongnam South Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jae\u2010Young","family":"Lim","sequence":"additional","affiliation":[{"name":"Department of Rehabilitation Medicine Seoul National University College of Medicine, Seoul National University Bundang Hospital  Seongnam South Korea"},{"name":"Seoul National University Institute on Aging  Seoul South Korea"},{"name":"Aging &amp; 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