{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:01:27Z","timestamp":1791820887949,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T00:00:00Z","timestamp":1697500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000156","name":"Fonds de Recherche du Qu\u00e9bec - Sant\u00e9","doi-asserted-by":"publisher","award":["career\u2010grant funding for C.G. (no. 31011)"],"award-info":[{"award-number":["career\u2010grant funding for C.G. (no. 31011)"]}],"id":[{"id":"10.13039\/501100000156","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2023,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Muscle weakness, and its association with mobility limitations, has received little study in oculopharyngeal muscular dystrophy (OPMD) using quantitative and standardized assessments. The objectives of this study were to (1) document upper and lower limb muscle strength, upper limb functions, fatigue, and mobility capacities; (2) compare them with reference values and across participant age groups; and (3) explore associations between muscle strength, fatigue, and mobility capacities among adults with OPMD.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thirty\u2010four participants were included in this cross\u2010sectional study. The following variables were assessed: quantitative maximal isometric muscle strength, grip and pinch strength, fatigue, walking speed, walking endurance, sit\u2010to\u2010stand, and stair ascent and descent capacities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Muscle strength was lower for older than younger participants for five muscle groups (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05). Walking endurance, sit\u2010to\u2010stand, stairs (ascent and descent), and strength of hip flexion, grip, and pinch were below 80% of reference values in participants \u226556\u2009y old (55.3%\u201378.2%). Moderate to strong correlations were found between muscle strength and mobility capacities (\u03c1\u2009=\u20090.42\u20130.80, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05), and between fatigue and either muscle strength or mobility capacities (\u03c1\u2009=\u20090.42\u20130.75, <jats:italic>P<\/jats:italic>\u2009&lt;\u2009.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This study highlights the impact of OPMD on strength, endurance, and functional capacity, among others, with patients being well below reference values even before the age of 65\u2009y. In addition to helping health professionals to offer better clinical guidance, these results will improve clinical trial readiness. The next steps will be to assess the metrological properties of outcome measures and continue to document the disease progression rate.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27984","type":"journal-article","created":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T06:01:21Z","timestamp":1697608881000},"page":"841-849","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Characterization of muscle strength and mobility in oculopharyngeal muscular dystrophy"],"prefix":"10.1002","volume":"68","author":[{"given":"Jean\u2010Denis","family":"Brisson","sequence":"first","affiliation":[{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9 Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux du Saguenay\u2010Lac\u2010St\u2010Jean  Saguenay Quebec Canada"},{"name":"Centre de recherche du Centre int\u00e9gr\u00e9 universitaire du Saguenay\u2013Lac\u2010St\u2010Jean, Clinique des maladies neuromusculaires  Saguenay Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Brais","sequence":"additional","affiliation":[{"name":"Department of Neurology McGill University, Montreal Neurological Institute  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9 Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux du Saguenay\u2010Lac\u2010St\u2010Jean  Saguenay Quebec Canada"},{"name":"Centre de recherche du Centre int\u00e9gr\u00e9 universitaire du Saguenay\u2013Lac\u2010St\u2010Jean, Clinique des maladies neuromusculaires  Saguenay Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Lessard","sequence":"additional","affiliation":[{"name":"Centre de recherche du Centre hospitalier universitaire de Sherbrooke (CRCHUS) Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Facult\u00e9 de m\u00e9decine et des sciences de la sant\u00e9 Universit\u00e9 de Sherbrooke  Sherbrooke Quebec Canada"},{"name":"Groupe de recherche interdisciplinaire sur les maladies neuromusculaires (GRIMN), Centre int\u00e9gr\u00e9 universitaire de sant\u00e9 et de services sociaux du 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