{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:58:04Z","timestamp":1775793484972,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T00:00:00Z","timestamp":1697760000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction\/Aims<\/jats:title><jats:p>Cough impairment is common in individuals with neuromuscular disorders and is associated with respiratory infections and shorter survival. Cough strength is assessed by measuring cough peak flow (CPF) using a flow meter, but this method requires a complex device setup and trained staff. The aim of the study is to evaluate the reliability of a smartphone app to estimate CPF based on cough sounds in a cohort of individuals with neuromuscular disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Individuals with neuromuscular disorders underwent CPF measurement with a flow meter and a smartphone app. A CPF &lt;270\u2009L\/min was considered abnormal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 50 patients studied, 26 had amyotrophic lateral sclerosis (52%), 15 had hereditary myopathies (30%), and 9 had myasthenia gravis (18%). The intraclass correlation coefficient (ICC) between the CPF measured with a flow meter and CPF estimated with cough sounds was 0.774 (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) even if the patients had orofacial weakness (ICC\u2009=\u20090.806, <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001). The smartphone app had 94.4% sensitivity and 100% specificity to detect patients with CPF of less than 270\u2009L\/min.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Our findings suggest that sounds measured with a smartphone app provide a reliable estimate of CPF in patients with neuromuscular disorders, even in the presence of with orofacial weakness. This may be a convenient way to monitor respiratory involvement in patients with neuromuscular disorders, but larger studies of more diverse patient cohorts are needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.27987","type":"journal-article","created":{"date-parts":[[2023,10,20]],"date-time":"2023-10-20T09:29:36Z","timestamp":1697794176000},"page":"213-217","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Sound\u2010based cough peak flow estimation in patients with neuromuscular disorders"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5481-3846","authenticated-orcid":false,"given":"Bernat Bertran","family":"Recasens","sequence":"first","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Neurology Department Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Bala\u00f1\u00e1 Corber\u00f3","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Pneumology Department, Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana Mar\u00eda Mart\u00ednez","family":"Llorens","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Pneumology Department, Hospital del Mar  Barcelona Spain"},{"name":"Hospital del Mar \u2013 Medical Research Institute (IMIM)  Barcelona Spain"},{"name":"Universitat Pompeu Fabra  Barcelona Spain"},{"name":"CIBER de Enfermedades Respiratorias (CIBERES), ISC III  Madrid Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Guillen\u2010Sola","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Physical Medicine and Rehabilitation Department Hospital del Mar  Barcelona Spain"},{"name":"Rehabilitation Research Group, Institut Hospital del Mar d'Investigacions M\u00e8diques (IMIM)  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Montserrat Villatoro","family":"Moreno","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Dietetics and Nutrition Department Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greta Garc\u00eda","family":"Escobar","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Neurology Department Hospital del Mar  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasutaka","family":"Umayahara","sequence":"additional","affiliation":[{"name":"Graduate School of Health Sciences Hiroshima Cosmopolitan University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zu","family":"Soh","sequence":"additional","affiliation":[{"name":"Graduate School of Advanced Science and Engineering Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshio","family":"Tsuji","sequence":"additional","affiliation":[{"name":"Graduate School of Advanced Science and Engineering Hiroshima University  Hiroshima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0735-6854","authenticated-orcid":false,"given":"Miguel \u00c1ngel","family":"Rubio","sequence":"additional","affiliation":[{"name":"ALS\/Motor Neuron Diseases Unit, Neurology Department Hospital del Mar  Barcelona Spain"},{"name":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red sobre Enfermedades Neurodegenerativas, Instituto de Salud Carlos III  Bellaterra Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,20]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/children5060078"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.5535\/ARM.21068"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2018.1510011"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.10.008"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00408\u2010020\u201000340\u20107"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010019\u201010060\u20107"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.118.5.1390"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/s18072381"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.588929"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.26606"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1080\/21678421.2022.2080560"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/s18113810"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1183\/13993003.01214\u20102018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.27361"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00417897"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/diagnostics10050334"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/73.2.145"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1088\/0967\u20103334\/36\/2\/243"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00455\u2010015\u20109687\u20101"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.27987","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,1,22]],"date-time":"2024-01-22T04:52:27Z","timestamp":1705899147000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.27987"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,20]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["10.1002\/mus.27987"],"URL":"https:\/\/doi.org\/10.1002\/mus.27987","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,10,20]]},"assertion":[{"value":"2023-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}