{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T06:51:53Z","timestamp":1788850313761,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T00:00:00Z","timestamp":1703808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Muscle and Nerve"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Myasthenia Gravis (MG) is an acquired autoimmune condition commonly diagnosed in young people of reproductive age resulting in neuromuscular junction dysfunction. The course of MG during pregnancy and its impact on maternal and neonatal outcomes is vary in the literature. Pregnancy planning is a known strategy and modifiable risk factor in obstetric practice to decrease maternal and neonatal morbidity. We aim to assess if planning a pregnancy impacts maternal and neonatal outcomes, MG exacerbation, and pregnancy\u2010related complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study utilized data from an online, North American survey entitled \u201cA Patient Centered study on Pregnancy in People with Myasthenia Gravis\u201d, distributed with the assistance of MG advocacy groups in the United States and Canada. It included individuals with MG who had at least one pregnancy in the last 10\u2010years. Key maternal and neonatal outcomes were compared between planned and unplanned pregnancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 156 survey participants, 58 had a pregnancy following MG diagnosis, totaling 90 reported pregnancies. Of these, 56 (62.2%) were planned and 34 (37.8%) were unplanned pregnancies.<\/jats:p><jats:p>The unplanned pregnancies were associated with more MG exacerbations, hospitalizations, and intensive care unit admission (37.7% vs. 13.7%, 26.5% vs. 11%, and 17.6% vs. 8.9%, respectively, <jats:italic>p<\/jats:italic>\u2009\u2264\u2009.05). The neonatal outcomes did not significantly differ between the groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Planned pregnancies in people with MG may be associated with a reduced gestational and post\u2010partum risk of MG exacerbation, hospitalizations, and ICU admissions. Larger studies are required to confirm this association and account for potential contributing variables.<\/jats:p><\/jats:sec>","DOI":"10.1002\/mus.28021","type":"journal-article","created":{"date-parts":[[2023,12,29]],"date-time":"2023-12-29T09:37:24Z","timestamp":1703842644000},"page":"318-324","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Pregnancy planning may impact maternal and neonatal outcomes in people with myasthenia gravis"],"prefix":"10.1002","volume":"69","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3098-6523","authenticated-orcid":false,"given":"Saja","family":"Anabusi","sequence":"first","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Accessible Care Pregnancy Clinic, Sunnybrook Health Sciences Centre  Toronto Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Izenberg","sequence":"additional","affiliation":[{"name":"Department of Neurology Sunnybrook Health Sciences Centre  Toronto Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina","family":"Barnett","sequence":"additional","affiliation":[{"name":"Division of Neurology, Department of Medicine University Health Network and University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Berndl","sequence":"additional","affiliation":[{"name":"Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology Accessible Care Pregnancy Clinic, Sunnybrook Health Sciences Centre  Toronto Canada"},{"name":"Department of Obstetrics and Gynecology University of Toronto  Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,29]]},"reference":[{"issue":"6","key":"e_1_2_10_2_1","first-page":"1978","article-title":"Myasthenia gravis and Lambert\u2010Eaton Myasthenic syndrome","volume":"22","author":"Nicolle MW","year":"2016","journal-title":"Continuum (Minneap Minn)"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000003339"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/GRF.0b013e31828e92c0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ncl.2018.01.011"},{"issue":"6","key":"e_1_2_10_6_1","first-page":"767","article-title":"Myasthenia gravis and pregnancy: Toronto specialty center experience","volume":"48","author":"Alharbi M","year":"2021","journal-title":"Can J Neurol Sci"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1212\/01.WNL.0000082725.21444.EC"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1970130618"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2474-5-42"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-2115(02)00051-9"},{"issue":"2","key":"e_1_2_10_11_1","first-page":"178","article-title":"Myasthenia gravis in pregnancy","volume":"80","author":"Mitchell PJ","year":"1992","journal-title":"Obstet Gynecol"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annfar.2004.01.014"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.11.014"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2009.02689.x"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nmd.2017.01.021"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.24556"},{"issue":"5","key":"e_1_2_10_17_1","first-page":"995","article-title":"Evaluation du b\u00e9n\u00e9fice apport\u00e9 par la programmation de la grossesse dans le diab\u00e8te sucr\u00e9 de type 1 [evaluation of the benefits brought by pregnancy planning in type 1 diabetes mellitus]","volume":"184","author":"Jaffiol C","year":"2000","journal-title":"Bull Acad Natl Med"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-020-01620-7"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203321989803"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-020-2139-9"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/mus.25095"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-1331.2006.01538.x"},{"key":"e_1_2_10_23_1","first-page":"299","volume-title":"Neurological and Neurosurgical Intensive Care","author":"Ropper AH","year":"2004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.08.031"}],"container-title":["Muscle &amp; Nerve"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mus.28021","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T10:46:27Z","timestamp":1707389187000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mus.28021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,29]]},"references-count":23,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/mus.28021"],"URL":"https:\/\/doi.org\/10.1002\/mus.28021","archive":["Portico"],"relation":{},"ISSN":["0148-639X","1097-4598"],"issn-type":[{"value":"0148-639X","type":"print"},{"value":"1097-4598","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,29]]},"assertion":[{"value":"2023-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-29","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}